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SLIRP - SRA stem-loop interacting RNA binding protein Gene

Also Known as DC50; PD04872; C14orf156

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81892

About SLIRP

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,708,071-77,717,598 (from NCBI)

This gene has 12 transcripts (splice variants), 173 orthologues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 31.5), kidney (RPKM 28.3) and 25 other tissues.

Summary

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]

SLIRP Products (3)

mRNA	Protein	Name
NM_001267863.1	NP_001254792.1	SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 2 precursor
NM_001267864.1	NP_001254793.1	SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 3 precursor
NM_031210.6	NP_112487.1	SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22045337	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLIRP Protein Structure

RRM_1

0
100
109 a.a.

Protein Preferred Names	Protein Names
SRA stem-loop-interacting RNA-binding protein, mitochondrial

SLIRP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLIRP	Q9GZT3	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	SLIRP	Q9GZT3	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	SLIRP	Q9GZT3	LRPPRC	Homo sapiens	P42704	Anti Tag CoIP	33961781
Intra	SLIRP	Q9GZT3	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	SLIRP	Q9GZT3	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	SLIRP	Q9GZT3	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	STK40	Homo sapiens	Q8N2I9	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	STK40	Homo sapiens	Q8N2I9	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	SLIRP	Q9GZT3	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SLIRP	Q9GZT3	WTAP	Homo sapiens	Q15007	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	WTAP	Homo sapiens	Q15007	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SLIRP	Q9GZT3	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mitochondrial Encephalomyopathy	Mitochondrial Encephalomyopathies Encephalomyopathy, Mitochondrial
Mitochondrial Complex Iv Deficiency, Nuclear Type 5	Leigh Syndrome, French Canadian Type Mitochondrial Complex V Deficiency Nuclear Type 4 Cytochrome C Oxidase Deficiency, French Canadian Type Lsfc Cox Deficiency, French Canadian Type MC5DN4 MC4DN5 Cox Deficiency, Saguenay-Lac-Saint-Jean Type Leigh Syndrome, Saguenay-Lac-Saint-Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 French Canadian Leigh Disease Leigh Syndrome, French-Canadian Type Leigh Syndrome , French Canadian Type Mitochondrial Complex V Deficiency, Atp5a1 Type French Canadian Type Cox Deficiency French Canadian Type Cytochrome C Oxidase Deficiency French Canadian Type Leigh Syndrome Saguenay Lac Saint Jean Type Cox Deficiency Saguenay Lac Saint Jean Type Leigh Syndrome Cox Deficiency, Saguenay Lac Saint Jean Type Leigh Syndrome, Saguenay Lac Saint Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 Mitochondrial Complex V Deficiency Atp5a1 Type Mitochondrial Complex V Deficiency Type 4 Mitochondrial Complex V Deficiency, Nuclear, Type 4
Chromosome 13q14 Deletion Syndrome	Chromosome 13q Deletion Syndrome Deletion 13q14 Chromosome 13q Deletion 13q Deletion 13q Monosomy Deletion 13q Monosomy 13q Monosomy 13q14 Del(13)(Q14)
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Spastic Ataxia	Spax Ataxia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13369	SLIRP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLIRP	VGNC	VGNC:51688
Bos taurus	SLIRP	VGNC	VGNC:55144
Macaca mulatta	SLIRP	VGNC	VGNC:99241
Mus musculus	SLIRP	MGD	MGI:1916394
Rattus norvegicus	SLIRP	RGD	RGD:1585290
Others	SLIRP	NCBI