WTAP - WT1 associated protein Gene

Also Known as Mum2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9589

About WTAP

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,726,693-159,756,319 (from NCBI)

This gene has 8 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in bone marrow (RPKM 44.8), lymph node (RPKM 20.4) and 25 other tissues.

Summary

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

WTAP Products (6)

mRNA Protein Name
NM_001270531.2 NP_001257460.1 pre-mRNA-splicing regulator WTAP isoform 1
NM_001270532.2 NP_001257461.1 pre-mRNA-splicing regulator WTAP isoform 3
NM_001270533.2 NP_001257462.1 pre-mRNA-splicing regulator WTAP isoform 3
NM_004906.5 NP_004897.2 pre-mRNA-splicing regulator WTAP isoform 1
NM_152857.3 NP_690596.1 pre-mRNA-splicing regulator WTAP isoform 2
NM_152858.3 NP_690597.1 pre-mRNA-splicing regulator WTAP isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA processing IMP
IMP: Inferred from mutant phenotype
24316715 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
24407421 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: Inferred from direct assay
24316715 GOA
part of RNA N6-methyladenosine methyltransferase complex IPI
IPI: Inferred from physical interaction
29507755 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
10942595 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
24100041 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
24100041 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10942595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pre-mRNA-splicing regulator WTAP

  • PNAS-132

WTAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WTAP Q15007 ZNF572 Homo sapiens Q7Z3I7
Validated Y2H
32296183
Intra
WTAP Q15007 SLIRP Homo sapiens Q9GZT3
Anti Tag CoIP
29507755
Intra
WTAP Q15007 SLIRP Homo sapiens Q9GZT3
Validated Y2H
32296183
Intra
WTAP Q15007 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra
WTAP Q15007 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra
WTAP Q15007 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra
WTAP Q15007 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
WTAP Q15007 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
Intra
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra
WTAP Q15007 ABHD15 Homo sapiens Q6UXT9
Validated Y2H
32296183
Intra
WTAP Q15007 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
WTAP Q15007 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra
WTAP Q15007 TNIP1 Homo sapiens Q15025
Validated Y2H
32296183
Intra
WTAP Q15007 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra
WTAP Q15007 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
WTAP Q15007 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
WTAP Q15007 ZNF239 Homo sapiens Q16600
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

WTAP Antibodies

Cat. No. Product Name Application Reactivity
HY-P81912 WTAP Antibody (YA1657) WB, IHC-P, IP Human
HY-P81912A WTAP Antibody (YA1657)(PBS only) WB, IHC-P, IP Human
HY-P83721 WTAP Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P84579 WTAP Antibody (YA4276) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat, Rabbit, Monkey
HY-P84579A WTAP Antibody (YA4276)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat, Rabbit, Monkey

Related Diseases

Diseases Alias
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Wilms Tumor 5

  • Wilms Tumor

  • WT5

  • Wilms Tumor Susceptibility-5

  • Wilms Tumor And Radial Bilateral Aplasia

  • Nephroblastoma

  • Wilms' Tumor

  • Wilms Tumor, Susceptibility To

  • Wtsl

  • Bilateral Radial Aplasia With Wilms Tumor

  • Embryonal Adenosarcoma

  • Embryonal Nephroma

  • Kidney Wilms Tumor

  • Kidney, Adenomyosarcoma, Embryonal

  • Kidney, Carcinosarcoma, Embryonal

  • Kidney, Embryoma

  • Kidney, Embryonal Mixed Tumor

  • Nephroma

  • Renal Adenosarcoma

  • Renal Cancer, Wilms

  • Renal Wilms Tumor

  • Tumor, Wilms

  • Hereditary Susceptibility To Wilms Tumor 5
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W037893 CHMA1004 dihydrochloride Activator 99.38% Unkown
HY-RS15854 WTAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W125425 CHMA1004 Activator / Unkown
HY-RS17418 Wtap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23872 Wtap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus WTAP RGD RGD:1563824
Mus musculus WTAP MGD MGI:1926395
Macaca mulatta WTAP VGNC VGNC:83971
Felis catus WTAP VGNC VGNC:84872
Canis familiaris WTAP VGNC VGNC:54003
Bos taurus WTAP VGNC VGNC:103059
Others WTAP NCBI