PRR5L - proline rich 5 like Gene

Also Known as PROTOR2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79899

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including TORC2 signaling; positive regulation of intracellular protein transport; and regulation of fibroblast migration. Part of TORC2 complex. [provided by Alliance of Genome Resources, Jun 2026]
Broad expression in spleen (RPKM 11.6), colon (RPKM 10.9) and 19 other tissues.

PRR5L Products (4)

mRNA Protein Name
NM_001160167.2 NP_001153639.1 proline-rich protein 5-like isoform a
NM_001160168.2 NP_001153640.1 proline-rich protein 5-like isoform b
NM_001160169.1 NP_001153641.1 proline-rich protein 5-like isoform c
NM_024841.5 NP_079117.3 proline-rich protein 5-like isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21964062 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
22609986 GOA
Biological Process GO Annotation Evidence References Source
involved in TORC2 signaling IDA
IDA: Inferred from direct assay
22609986 GOA
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
21964062 GOA
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22609986 GOA
involved in positive regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
21964062 GOA
involved in positive regulation of mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
21964062 GOA
involved in regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
22609986 GOA
Cellular Component GO Annotation Evidence References Source
part of TORC2 complex IDA
IDA: Inferred from direct assay
22609986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR5L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRR5L Q6MZQ0 CCDC91 Homo sapiens Q7Z6B0-2
Y2H Array
32296183
Intra
PRR5L Q6MZQ0 CCDC91 Homo sapiens Q7Z6B0-2
Validated Y2H
32296183
Intra
PRR5L Q6MZQ0 CCDC91 Homo sapiens Q7Z6B0-2
Y2H Prey Pooling
32296183
Intra
PRR5L Q6MZQ0 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
PRR5L Q6MZQ0 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
PRR5L Q6MZQ0 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
PRR5L Q6MZQ0 MISP Homo sapiens Q8IVT2
Validated Y2H
32296183
Intra
PRR5L Q6MZQ0 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
PRR5L Q6MZQ0 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
PRR5L Q6MZQ0 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
PRR5L Q6MZQ0 MAD2L2 Homo sapiens Q9UI95
Validated Y2H
32296183
Intra
PRR5L Q6MZQ0 PHAF1 Homo sapiens Q9BSU1
Y2H Prey Pooling
32296183
Intra
PRR5L Q6MZQ0 PHAF1 Homo sapiens Q9BSU1
Validated Y2H
32296183
Intra
PRR5L Q6MZQ0 PHAF1 Homo sapiens Q9BSU1
Y2H Array
32296183
Intra
PRR5L Q6MZQ0 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11232 PRR5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown