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CIAPIN1 Antibody (YA7899)(PBS only)

(Synonyms: Anamorsin; DRE2; PRO0915)

CIAPIN1 Antibody (YA7899) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CIAPIN1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CIAPIN1 Antibody (YA7899)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:1000-4000 1:150-500

Product Details

Description

CIAPIN1 Antibody (YA7899) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CIAPIN1.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 33.4 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 97-312 of human CIAPIN1 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CIAPIN1 component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells[1].

  • Subcellular Localization

    Cytoplasm,Nucleus,Mitochondrion intermembrane space

  • Expression


    Tissue_Specificity: Ubiquitously expressed. Highly expressed in heart, liver and pancreas

  • Isoforms & Post-Translational Modification

    Q6FI81 has three isomers: Q6FI81-1: 33582 Da (predicted); Q6FI81-2: 11735 Da (predicted); Q6FI81-3: 32213 Da (predicted).

  • Subunit

    Monomer

  • SwissProt ID

    Q6FI81

  • Synonyms

    Anamorsin; DRE2; PRO0915

CIAPIN1 Antibody (YA7899)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CIAPIN1 Antibody (YA7899)(PBS only) Product Image