71422-67-8
Chemical Structure
Chlorfluazuron
Synonym(s): IKI-7899
- CAS. Nr.: 71422-67-8
- Formula:C20H9Cl3F5N3O3
- Molecular Weight:540.65
IUPAC Name: N-((3,5-dichloro-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)carbamoyl)-2,6-difluorobenzamide
InChIKey: UISUNVFOGSJSKD-UHFFFAOYSA-N
SMILES: O=C(NC(NC1=CC(Cl)=C(OC2=NC=C(C(F)(F)F)C=C2Cl)C(Cl)=C1)=O)C3=C(F)C=CC=C3F
Biological Activity: Chlorfluazuron (IKI-7899) is a benzoylurea chitin synthesis inhibitor and a PPARγ agonist ligand that blocks the polymerization of UDP-N-acetylglucosamine by inhibiting chitin synthase, disrupting cuticle formation, molting, and embryonic development, thereby exerting ovicidal, larvicidal, and fecundity-reducing effects in insects. Chlorfluazuron is used in hepatotoxicity research[1][2][3][4][5][6][7][8][9].
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Chlorfluazuron | 98.89% | Chlorfluazuron (IKI-7899) is a benzoylurea chitin synthesis inhibitor and a PPARγ agonist ligand that blocks the polymerization of UDP-N-acetylglucosamine by inhibiting chitin synthase, disrupting cuticle formation, molting, and embryonic development, thereby exerting ovicidal, larvicidal, and fecundity-reducing effects in insects. Chlorfluazuron is used in hepatotoxicity research. | ||||||||||||||||||||
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Chlorfluazuron (Standard) | ≥98% | Chlorfluazuron (Standard) (IKI-7899 (Standard)) is the analytical standard of Chlorfluazuron (HY-133204). This product is intended for research and analytical applications. Chlorfluazuron (IKI-7899) is a benzoylurea chitin synthesis inhibitor and a PPARγ agonist ligand that blocks the polymerization of UDP-N-acetylglucosamine by inhibiting chitin synthase, disrupting cuticle formation, molting, and embryonic development, thereby exerting ovicidal, larvicidal, and fecundity-reducing effects in insects. Chlorfluazuron is used in hepatotoxicity research. | ||||||||||||||||||||
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References
- [1]. Gad HA, et al. Long term efficacy of three chitin synthesis inhibitors and oxymatrine as ecofriendly seed protectants against Callosobruchus maculatus and Callosobruchus chinensis. Journal of Stored Products Research. 2024 Feb 1;105:102243.
- [2]. Abdel-Aal AE. Effect of three insect growth regulators (Chlorfluazuron, et al. littoralis, histopathological and some biochemical aspects of moth ovary. Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control. 2012 Dec 1;4(1):49-59.
- [3]. Zhang P, et al. Lethal and sublethal effects of the chitin synthesis inhibitor chlorfluazuron on Bradysia odoriphaga Yang and Zhang (Diptera: Sciaridae). Pesticide Biochemistry and Physiology. 2017 Mar 1;136:80-8.
- [4]. Retnakaran A, et al. Control of insect pests with benzoylphenyl ureas. InChitin and benzoylphenyl ureas 1987 (pp. 205-282). Dordrecht: Springer Netherlands.
- [5]. Shennawy Rania. Toxicological, biochemical and ultrastructural alterations induced by chlorfluazuron and Bacillus thuringiensis (diple d.f.) on Pectinophora gossypiella (saunders) larvae. Egyptian Journal of Agricultural Research. 2020. 98. 410-434.
- [6]. Ning X, et al. In vitro PPARγ agonistic potential of chitin synthesis inhibitors and their energy metabolism-related hepatotoxicity. The Science of the total environment. 2018 Feb 15;615:1126-1132.
- [7]. Mobarak SA. The malformation effect of chlorfluazuron on the reproductive system of land snail Eobania vermiculata. The Journal of Basic & Applied Zoology. 2016 Mar 1;74:51-5.
- [8]. Zhu N, et al. Photo-degradation behavior of seven benzoylurea pesticides with CN nanofilm and its aquatic impacts on Scendesmus obliquus. The Science of the total environment. 2021 Dec 10;799:149470.
- [9]. Liu S, et al. Compatibility and synergistic interactions between Metarhizium rileyi and five chitin synthesis inhibitors against Spodoptera frugiperda (Lepidoptera: Noctuidae). Crop Protection. 2026 Aug 21:107842.
