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KLF12 - KLF transcription factor 12 Gene

Also Known as AP2REP; AP-2rep; HSPC122

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11278

About KLF12

Cytogenetic location: 13q22.1 Genomic coordinates (GRCh38): 13:73,686,089-74,306,045 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 22 paralogues. Ubiquitous expression in lymph node (RPKM 6.4), spleen (RPKM 4.4) and 24 other tissues.

Summary

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like Zinc Finger Protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

KLF12 Products (12)

mRNA	Protein	Name
NM_001400136.1	NP_001387065.1	Krueppel-like factor 12 isoform 1
NM_001400139.1	NP_001387068.1	Krueppel-like factor 12 isoform 1
NM_001400141.1	NP_001387070.1	Krueppel-like factor 12 isoform 1
NM_001400146.1	NP_001387075.1	Krueppel-like factor 12 isoform 2
NM_001400147.1	NP_001387076.1	Krueppel-like factor 12 isoform 3
NM_001400148.1	NP_001387077.1	Krueppel-like factor 12 isoform 3
NM_001400149.1	NP_001387078.1	Krueppel-like factor 12 isoform 4
NM_001400150.1	NP_001387079.1	Krueppel-like factor 12 isoform 5
NM_001400151.1	NP_001387080.1	Krueppel-like factor 12 isoform 5
NM_001400152.1	NP_001387081.1	Krueppel-like factor 12 isoform 6
NM_001400153.1	NP_001387082.1	Krueppel-like factor 12 isoform 6
NM_007249.5	NP_009180.3	Krueppel-like factor 12 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16615998	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16615998	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10704285	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10704285	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16615998	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10704285	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF12 Protein Structure

zf-H2C2_2

0
100
200
300
402 a.a.

Protein Preferred Names	Protein Names
Krueppel-like factor 12	AP-2 repressor

KLF12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KLF12	Q9Y4X4	CTBP1	Homo sapiens	Q13363-2	Validated Y2H	27107012
Intra	KLF12	Q9Y4X4	CTBP1	Homo sapiens	Q13363-2	Y2H Prey Pooling	25416956
Intra	KLF12	Q9Y4X4	CTBP1	Homo sapiens	Q13363-2	Y2H Array	25416956
Intra	KLF12	Q9Y4X4	CTBP1	Homo sapiens	Q13363-2	BFG-2H	27107012
Intra	KLF12	Q9Y4X4	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	KLF12	Q9Y4X4	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	KLF12	Q9Y4X4	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	KLF12	Q9Y4X4	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	KLF12	Q9Y4X4	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	KLF12	Q9Y4X4	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	25416956
Intra	KLF12	Q9Y4X4	EHMT2	Homo sapiens	Q96KQ7	Y2H Prey Pooling	32296183
Intra	KLF12	Q9Y4X4	EHMT2	Homo sapiens	Q96KQ7	BioID	35140242
Intra	KLF12	Q9Y4X4	EHMT2	Homo sapiens	Q96KQ7	Y2H Array	32296183
Intra	KLF12	Q9Y4X4	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	KLF12	Q9Y4X4	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	KLF12	Q9Y4X4	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07333	KLF12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KLF12	VGNC	VGNC:74028
Rattus norvegicus	KLF12	RGD	RGD:1309204
Felis catus	KLF12	VGNC	VGNC:102241
Canis familiaris	KLF12	VGNC	VGNC:42432
Mus musculus	KLF12	MGD	MGI:1333796
Bos taurus	KLF12	VGNC	VGNC:30628
Others	KLF12	NCBI