TYK2 - tyrosine kinase 2 Gene

Also Known as JTK1; IMD35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7297

About TYK2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,350,533-10,380,572 (from NCBI)

This gene has 35 transcripts (splice variants), 197 orthologues, 32 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues.

Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II Cytokine Receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]

TYK2 Products (21)

mRNA	Protein	Name
NM_001385200.1	NP_001372129.1	non-receptor tyrosine-protein kinase TYK2 isoform 6
NM_001385197.1	NP_001372126.1	non-receptor tyrosine-protein kinase TYK2 isoform 3
NM_001385204.1	NP_001372133.1	non-receptor tyrosine-protein kinase TYK2 isoform 1
NM_001385199.1	NP_001372128.1	non-receptor tyrosine-protein kinase TYK2 isoform 5
NM_001406461.1	NP_001393390.1	non-receptor tyrosine-protein kinase TYK2 isoform 2
XM_047439305.1	XP_047295261.1	non-receptor tyrosine-protein kinase TYK2 isoform X4
NM_001385202.1	NP_001372131.1	non-receptor tyrosine-protein kinase TYK2 isoform 8
NM_001385206.1	NP_001372135.1	non-receptor tyrosine-protein kinase TYK2 isoform 11
XM_011528249.3	XP_011526551.1	non-receptor tyrosine-protein kinase TYK2 isoform X5
NM_001385201.1	NP_001372130.1	non-receptor tyrosine-protein kinase TYK2 isoform 7
XM_011528245.2	XP_011526547.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
NM_003331.5	NP_003322.3	non-receptor tyrosine-protein kinase TYK2 isoform 2
XM_047439304.1	XP_047295260.1	non-receptor tyrosine-protein kinase TYK2 isoform X2
NM_001385207.1	NP_001372136.1	non-receptor tyrosine-protein kinase TYK2 isoform 12
XM_047439307.1	XP_047295263.1	non-receptor tyrosine-protein kinase TYK2 isoform X7
XM_011528246.4	XP_011526548.1	non-receptor tyrosine-protein kinase TYK2 isoform X3
XM_011528247.2	XP_011526549.1	non-receptor tyrosine-protein kinase TYK2 isoform X3
NM_001385205.1	NP_001372134.1	non-receptor tyrosine-protein kinase TYK2 isoform 10
XM_047439306.1	XP_047295262.1	non-receptor tyrosine-protein kinase TYK2 isoform X6
NM_001385203.1	NP_001372132.1	non-receptor tyrosine-protein kinase TYK2 isoform 9
NM_001385198.1	NP_001372127.1	non-receptor tyrosine-protein kinase TYK2 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth hormone receptor binding	IPI IPI: Inferred from physical interaction	10502458	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7526154	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	1386289	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10542297	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	7526154	GOA
involved in interleukin-10-mediated signaling pathway	IDA IDA: Inferred from direct assay	7543512	GOA
involved in interleukin-12-mediated signaling pathway	IDA IDA: Inferred from direct assay	7528775	GOA
involved in interleukin-23-mediated signaling pathway	IDA IDA: Inferred from direct assay	7528775	GOA
involved in positive regulation of NK T cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	11114383	GOA
involved in positive regulation of natural killer cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	8605876	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	7638186	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	12023369	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	8232552	GOA
involved in type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	8232552	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10502458	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10502458	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TYK2 Protein Structure

Pkinase_Tyr

0
200
400
600
800
1000
1187 a.a.

Protein Preferred Names	Protein Names
non-receptor tyrosine-protein kinase TYK2

TYK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TYK2	P29597	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	TYK2	P29597	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	TYK2	P29597	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	TYK2	P29597	PRDM5	Homo sapiens	Q9NQX1-2	Validated Y2H	32296183
Intra	TYK2	P29597	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Array	32296183
Intra	TYK2	P29597	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	STAT2	Homo sapiens	P52630	Anti Tag CoIP	32953130
Intra	TYK2	P29597	IFNAR1	Homo sapiens	P17181-1	Pull Down	24704786
Intra	TYK2	P29597	IFNAR1	Homo sapiens	P17181-1	GMS	24704786
Intra	TYK2	P29597	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	TYK2	P29597	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	TYK2	P29597	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	TYK2	P29597	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	TYK2	P29597	HNRNPK	Homo sapiens	P61978	Y2H Array	29892012
Intra	TYK2	P29597	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	TYK2	P29597	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	TYK2	P29597	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	TYK2	P29597	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25416956
Intra	TYK2	P29597	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	TYK2	P29597	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	JAK2	Homo sapiens	O60674	Anti Bait CoIP	26175413
Intra	TYK2	P29597	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TYK2	P29597	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	TYK2	P29597	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	TYK2	P29597	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	TYK2	P29597	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	TYK2	P29597	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	TYK2	P29597	FHL3	Homo sapiens	Q13643	Validated Y2H	25416956
Intra	TYK2	P29597	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	TYK2	P29597	KHDRBS2	Homo sapiens	Q5VWX1	Y2H	21516116
Intra	TYK2	P29597	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	32296183
Intra	TYK2	P29597	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	TYK2	P29597	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	TYK2	P29597	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	TYK2	P29597	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	TYK2	P29597	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TYK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85402	Tyk 2 Antibody (YA5094)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Alopecia Universalis Congenita	Alopecia Universalis ALUNC Atrichia, Generalized Au Alopecia Areata Universalis Atrichia Generalized
Hyper Ige Recurrent Infection Syndrome 1	Job Syndrome Hyper-Ige Recurrent Infection Syndrome 1 Hyperimmunoglobulin E Syndrome Job'S Syndrome Recurring Cold Staphylococcal Abscesses Ige Syndromes Buckley Syndrome Hie - [Hyperimmunoglobulin E] Syndrome Job-Buckley Syndrome Quie-Hill Syndrome
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Immunodeficiency 35	Tyrosine Kinase 2 Deficiency IMD35 Tyk2 Deficiency Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis Susceptibility To Infection Due To Tyk2 Deficiency Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive Hies With Atypical Mycobacteriosis, Autosomal Recessive Autosomal Recessiv Hies With Atypical Mycobacteriosis Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency Autosomal Recessive Hies With Atypical Mycobacteriosis
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Autoimmune Disease Of Skin And Connective Tissue
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Primary Cutaneous Anaplastic Large Cell Lymphoma	Primary C-Alcl Regressive Atypical Histiocytosis Lymphoma, Primary Cutaneous Anaplastic Large Cell
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Crisponi/Cold-Induced Sweating Syndrome 2	Cold-Induced Sweating Syndrome 2 CISS2 Sweating Syndrome, Cold-Induced, Type 2
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp XLP1 Lyp X-Linked Lymphoproliferative Disease Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Lymphopenia	Lymphocytopenia
Erythematosquamous Dermatosis	Other Erythematosquamous Dermatosis
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Mixed Lacrimal Gland Cancer	Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland Malignant Mixed Neoplasm Of Lacrimal Gland

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50856	Ruxolitinib	Inhibitor	99.99%	Yes
HY-19569	Upadacitinib	Inhibitor	99.98%	Yes
HY-15315	Baricitinib	Inhibitor	99.97%	Yes
HY-117287	Deucravacitinib	Inhibitor	99.93%	Unkown
HY-50858	Ruxolitinib phosphate	Inhibitor	99.97%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-107429	Abrocitinib	Inhibitor	99.26%	Unkown
HY-18300	Filgotinib	Inhibitor	99.77%	Yes
HY-19568	Peficitinib	Inhibitor	99.43%	Yes
HY-15315A	Baricitinib phosphate	Inhibitor	99.97%	Yes
HY-109053	Delgocitinib	Inhibitor	99.61%	Unkown
HY-13577	Oclacitinib	Inhibitor	99.03%	Unkown
HY-13577A	Oclacitinib monomaleate	Inhibitor	99.87%	Unkown
HY-18300A	Filgotinib maleate	Inhibitor	99.88%	Yes
HY-50859	Ruxolitinib sulfate	Inhibitor	/	Unkown
HY-19569A	Upadacitinib tartrate tetrahydrate	Inhibitor	/	Unkown
HY-19568A	Peficitinib hydrobromide	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-19568B	Peficitinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15999	Cerdulatinib	Inhibitor	99.06%	Phase 3
HY-12469	Decernotinib	Inhibitor	99.91%	Phase 3
HY-112724	Ivarmacitinib	Inhibitor	99.62%	Phase 3
HY-174905	Quecitinib	Inhibitor	99.56%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	98.96%	Phase 3
HY-13034	Gandotinib	Inhibitor	99.86%	Phase 2
HY-15270	BMS-911543	Inhibitor	98.23%	Phase 2
HY-19631A	Ilginatinib	Inhibitor	99.81%	Phase 2
HY-156961	Cadefrecitinib	Inhibitor	99.81%	Phase 2
HY-19631B	Ilginatinib hydrochloride	Inhibitor	98.92%	Phase 2
HY-19631	Ilginatinib maleate	Inhibitor	99.33%	Phase 2
HY-101024	PF-06263276	Inhibitor	≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14435	Pyridone 6	Inhibitor	98.20%	Unkown
HY-14722	NVP-BSK805	Inhibitor	99.30%	Unkown
HY-131968	BMS-986202	Inhibitor	99.29%	Unkown
HY-100895	SAR-20347	Inhibitor	97.27%	Unkown
HY-158142	PROTAC TYK2 degrader-1	Degrader	99.55%	Unkown
HY-113787	(R)-9b	Inhibitor	99.51%	Unkown
HY-160144S	Lomedeucitinib	Inhibitor	99.75%	Unkown
HY-153701S	Envudeucitinibum	Inhibitor	99.56%	Unkown
HY-14722A	NVP-BSK805 dihydrochloride	Inhibitor	99.36%	Unkown
HY-16640	TCJL37	Inhibitor	99.89%	Unkown
HY-126242S	Tyk2-IN-7	Inhibitor	99.58%	Unkown
HY-101762	TyK2-IN-2	Inhibitor	99.05%	Unkown
HY-111745	Tyk2-IN-5	Inhibitor	99.35%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	98.31%	Unkown
HY-150720	TYK2-IN-12	Inhibitor	98.81%	Unkown
HY-120469	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	Inhibitor	99.80%	Unkown
HY-153440	Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate	Inhibitor	98.01%	Unkown
HY-111750	JAK-IN-3	Inhibitor	98.92%	Unkown
HY-13961	GLPG0634 analog	Inhibitor	98.07%	Unkown
HY-126141	JAK/HDAC-IN-1	Inhibitor	98.63%	Unkown
HY-152080	Blovacitinib	Inhibitor	99.71%	Unkown
HY-159536	Frevecitinib	Inhibitor	99.42%	Unkown
HY-143884	JAK2/TYK2-IN-1	Inhibitor	99.94%	Unkown
HY-148060	JAK-IN-21	Inhibitor	99.72%	Unkown
HY-18710	BMS-066	Inhibitor	99.09%	Unkown
HY-170772	Dual Cathepsin L/JAK-IN-1	Inhibitor	98.47%	Unkown
HY-18315	Bayer-18	Inhibitor	/	Unkown
HY-184075S	Nomelcitinib	Inhibitor	/	Unkown
HY-14722C	NVP-BSK805 trihydrochloride	Inhibitor	/	Unkown
HY-154994	JAK-IN-30	Inhibitor	/	Unkown
HY-177131	Soficitinib	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-177130S	Socrodeucitinib	Inhibitor	/	Unkown
HY-N14094	Tubulosine	Inhibitor	/	Unkown
HY-174430	WWQ-131	Inhibitor	/	Unkown
HY-168269	Tyk2-IN-20	Inhibitor	/	Unkown
HY-181278	Deucravacitinib analog 1		/	Unkown
HY-401428	TYK2 ligand 3	Degrader	/	Unkown
HY-175684	JAK2-IN-14	Inhibitor	/	Unkown
HY-163304	Tyk2-IN-16	Inhibitor	/	Unkown
HY-175983	JAK1/TYK2-IN-5	Inhibitor	/	Unkown
HY-158692	Tyk2-IN-18	Inhibitor	/	Unkown
HY-158340	TYK2 ligand 1	Inhibitor	/	Unkown
HY-168339	Tyk2-IN-22	Inhibitor	/	Unkown
HY-18709	Tyk2-IN-3	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-175310S	Voderdeucitinib	Inhibitor	/	Unkown
HY-178282	JAK1-IN-19	Inhibitor	/	Unkown
HY-149296	JAK1-IN-12	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-176793	JAK1-IN-18	Inhibitor	/	Unkown
HY-112783	TYK2 ligand 4	Ligand	/	Unkown
HY-173359	TYK2 ligand 2	Ligand	/	Unkown
HY-162862	JAK-IN-38	Inducer	/	Unkown
HY-157121	JAK-IN-34	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inhibitor	/	Unkown
HY-123187	AS2553627	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TYK2	VGNC	VGNC:78680
Mus musculus	TYK2	MGD	MGI:1929470
Felis catus	TYK2	VGNC	VGNC:66736
Rattus norvegicus	TYK2	RGD	RGD:2320469
Canis familiaris	TYK2	VGNC	VGNC:48024
Bos taurus	TYK2	VGNC	VGNC:36548
Others	TYK2	NCBI