TYK2 ligand 2
TYK2 ligand 2 is a PROTAC target protein ligand that targets TYK2 and can be used for PROTAC synthesis-related research, such as PROTAC TYD-68 (HY-173357).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2924460-80-8
- 分子式: C24H20FN7O4
- 分子量:489.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Tyk2 |
体外実験
TYK2 ligand 2 can serve as a target protein ligand for TYD-68 (HY-173357). TYD-68 is a TYK2 PROTAC degrader that recruits CRBNs, with a DC50 of 0.42 nM, and is selective for JAK1/JAK2-dependent signaling pathways. TYD-68 can inhibit TYK2-mediated signal transduction, downregulate TYK2 protein expression levels, and reduce the secretion of pro-inflammatory factors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2924460-80-8
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分子量 489.46
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分子式 C24H20FN7O4
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SMILES
COC1=C(C=CC=C1C2=NC=C(C=N2)F)NC3=CC(NC4=CC=C(C=N4)C(O)=O)=NC=C3C(NC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TYK2 ligand 2 関連分類
HY-173359 関連分類
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