1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. Tyk2-IN-5

Tyk2-IN-5 

Cat. No.: HY-111745 Purity: 99.78%
Handling Instructions

Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model.

For research use only. We do not sell to patients.

Tyk2-IN-5 Chemical Structure

Tyk2-IN-5 Chemical Structure

CAS No. : 1797432-62-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1].

IC50 & Target[1]

Tyk2 JH2

0.086 nM (Ki)

IFNα

25 nM (IC50)

Molecular Weight

434.43

Formula

C₂₁H₁₉FN₈O₂

CAS No.

1797432-62-2

SMILES

O=C1C(NC2=NN3C(C(NC)=C2)=NC=C3C(N[[email protected]]4[[email protected]@H](F)C4)=O)=CC=CN1C5=CC=CC=N5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 43.33 mg/mL (99.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3019 mL 11.5093 mL 23.0187 mL
5 mM 0.4604 mL 2.3019 mL 4.6037 mL
10 mM 0.2302 mL 1.1509 mL 2.3019 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Tyk2-IN-5
Cat. No.:
HY-111745
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