2. Others Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Isotope-Labeled Compounds JAK
  4. Tyk2-IN-8

Tyk2-IN-8 is a selective Tyk-2 inhibitor with an IC50 of 5.7 nM for TYK2-JH2. Tyk2-IN-8 inhibits JAK1-JH1 with IC50 of 3.0 nM. Tyk2-IN-8 can be used for the research of autoimmune disease[1].

For research use only. We do not sell to patients.

Tyk2-IN-8 Chemical Structure

Tyk2-IN-8 Chemical Structure

CAS No. : 2704587-24-4

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1 mg USD 810 In-stock
5 mg USD 2050 In-stock
10 mg USD 3250 In-stock
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Based on 1 publication(s) in Google Scholar

Tyk2-IN-8 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

Tyk2-IN-8 is a selective Tyk-2 inhibitor with an IC50 of 5.7 nM for TYK2-JH2. Tyk2-IN-8 inhibits JAK1-JH1 with IC50 of 3.0 nM. Tyk2-IN-8 can be used for the research of autoimmune disease[1].

Molecular Weight

425.46

Formula

C20H19D3N8O3
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

[2H]C([2H])([2H])OC1=C(C2=NN(C)C=N2)C=CC=C1NC3=C(N=NC(NC(C4CC4)=O)=C3)C(NC)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (235.04 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3504 mL 11.7520 mL 23.5040 mL
5 mM 0.4701 mL 2.3504 mL 4.7008 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3504 mL 11.7520 mL 23.5040 mL 58.7599 mL
5 mM 0.4701 mL 2.3504 mL 4.7008 mL 11.7520 mL
10 mM 0.2350 mL 1.1752 mL 2.3504 mL 5.8760 mL
15 mM 0.1567 mL 0.7835 mL 1.5669 mL 3.9173 mL
20 mM 0.1175 mL 0.5876 mL 1.1752 mL 2.9380 mL
25 mM 0.0940 mL 0.4701 mL 0.9402 mL 2.3504 mL
30 mM 0.0783 mL 0.3917 mL 0.7835 mL 1.9587 mL
40 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4690 mL
50 mM 0.0470 mL 0.2350 mL 0.4701 mL 1.1752 mL
60 mM 0.0392 mL 0.1959 mL 0.3917 mL 0.9793 mL
80 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7345 mL
100 mM 0.0235 mL 0.1175 mL 0.2350 mL 0.5876 mL
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Tyk2-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyk2-IN-82704587-24-4Isotope-Labeled CompoundsJAKJanus kinaseselective Tyk-2 inhibitorTYK2-JH2autoimmune diseaseInhibitorinhibitorinhibit

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