Tyk2-IN-25
Tyk2-IN-25 is a TYK2 inhibitor that binds to the JH2 domain of TYK2. Tyk2-IN-25 inhibits p-STAT4 and p-STAT3 in human peripheral blood mononuclear cells. Tyk2-IN-25 is applicable to research related to multiple diseases such as immune and inflammatory diseases, and neurological diseases.
For research use only. We do not sell to patients.
- CAS No.: 2417137-50-7
- Formula: C20H22N8O3
- Molecular Weight:422.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Tyk2 JH2 |
p-STAT3 |
Tyk2-IN-25 (compound 40) binds to TYK2 (JH2 domain-pseudokinase) with a Kd value ≤ 1 nM; it inhibits IL-12-induced p-STAT4 and p-STAT3 in human peripheral blood mononuclear cells (PBMC) with an IC50 ranging from 100 nM to 1 μM; it also inhibits INFα-induced p-STAT3 in human peripheral blood mononuclear cells (PBMC) with an IC50 ranging from 100 nM to 1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2417137-50-7
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Molecular Weight 422.44
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Formula C20H22N8O3
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SMILES
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyk2-IN-25 Related Classifications
HY-184833 Related Classifications
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