1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Tyk2-IN-4 

Cat. No.: HY-117287
Handling Instructions

Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).

For research use only. We do not sell to patients.

Tyk2-IN-4 Chemical Structure

Tyk2-IN-4 Chemical Structure

CAS No. : 1609392-27-9

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Customer Review

View All JAK Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).

IC50 & Target[1]

Tyk2

 

In Vitro

Tyk2-IN-4 blocks receptor-mediated Tyk2 activation by stabilizing the regulatory pseudokinase domain of the protein[1].

In Vivo

Lupus-like disease is strongly inhibited in NZB/W mice treated with Tyk2-IN-4. Tyk2-IN-4 is safe and overall well-tolerated. There are no serious adverse events and the frequency of non-serious adverse events are similar in the active (75%) and placebo (76%) groups. After oral administration, Tyk2-IN-4 is rapidly absorbed and exhibits an apparent elimination half-life of 8-15 hours[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3504 mL 11.7520 mL 23.5040 mL
5 mM 0.4701 mL 2.3504 mL 4.7008 mL
10 mM 0.2350 mL 1.1752 mL 2.3504 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

425.46

Formula

C₂₀H₁₉D₃N₈O₃

CAS No.

1609392-27-9

SMILES

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[2H]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Tyk2-IN-4
Cat. No.:
HY-117287
Quantity:

Tyk2-IN-4

Cat. No.: HY-117287