1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

NS-018 maleate 

Cat. No.: HY-19631 Purity: 98.33%
Data Sheet SDS Handling Instructions

NS-018 maleate is an ATP-competitive small-molecule inhibitor of JAK2 with IC50 of 470 nM in Ba/F3-JAK2V617F cells, have30-50-fold greater selectivity for JAK2 over other JAK-family kinases, such as JAK1, JAK3 and tyrosine kinase 2.

For research use only. We do not sell to patients.
NS-018 maleate Chemical Structure

NS-018 maleate Chemical Structure

CAS No. : 1354799-87-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $389 In-stock
1 mg $150 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of NS-018 maleate:

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  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

NS-018 maleate is an ATP-competitive small-molecule inhibitor of JAK2 with IC50 of 470 nM in Ba/F3-JAK2V617F cells, have30-50-fold greater selectivity for JAK2 over other JAK-family kinases, such as JAK1, JAK3 and tyrosine kinase 2. target: JAK2 IC 50: 470 nM In vitro: NS-018 suppressed the phosphorylation of STAT3 in colony-forming cells. NS-018 inhibited Src-family kinases. NS-018 showed potent antiproliferative activity against cell lines expressing a constitutively activated JAK2. NS-018 also markedly reduced splenomegaly and prolonged the survival of mice inoculated with Ba/F3 cells harboring JAK2V617F. In vivo: NS-018 significantly reduced leukocytosis, hepatosplenomegaly and extramedullary hematopoiesis, improved nutritional status, and prolonged survival in JAK2V617F transgenic mice. NS-018 also inhibited erythroid colony formation in JAK2V617F transgenic mice at significantly lower concentrations than in WT mice.

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References
Molecular Weight

505.5

Formula

C₂₅H₂₄FN₇O₄

CAS No.

1354799-87-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
NS-018 maleate
Cat. No.:
HY-19631
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