1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

NS-018 

Cat. No.: HY-19631A
Handling Instructions

NS-018 is a novel highly selective JAK2 inhibitor. NS-018 suppresses the growth of Ba/F3-JAK2V617F cells with an IC50 value of 470 nM, whereas NS-018 suppresses the growth of Ba/F3-JAK2WT cells stimulated with IL-3 with an IC50 value of 2000 nM.

For research use only. We do not sell to patients.
NS-018 Chemical Structure

NS-018 Chemical Structure

CAS No. : 1239358-86-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $385 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of NS-018:

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Description

NS-018 is a novel highly selective JAK2 inhibitor. NS-018 suppresses the growth of Ba/F3-JAK2V617F cells with an IC50 value of 470 nM, whereas NS-018 suppresses the growth of Ba/F3-JAK2WT cells stimulated with IL-3 with an IC50 value of 2000 nM. IC50 value: 470 nM (for Ba/F3-JAK2V617F cell) Target: JAK2 in vitro: NS-018 suppresses the phosphorylation of STAT3 in colony-forming cells from MDS patients. Collectively, NS-018 could be a new therapeutic option for high-risk MDS. [1] in vivo: Specifically, in JAK2V617F transgenic mice, NS-018 inhibits erythroid colony growth with a mean IC50 value of 360 nM, whereas in WT control mice the corresponding IC50 value was >600 nM. These results show that NS-018 preferentially suppressed the growth of cells harboring JAK2V617F.[2]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01423851 NS Pharma, Inc. Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Post-Essential Thrombocythemia Myelofibrosis June 2011 Phase 1|Phase 2
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References
Molecular Weight

389.43

Formula

C₂₁H₂₀FN₇

CAS No.

1239358-86-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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NS-018
Cat. No.:
HY-19631A
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