1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Upadacitinib (Synonyms: ABT-494)

Cat. No.: HY-19569 Purity: 99.40%
Handling Instructions

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM.

For research use only. We do not sell to patients.

Upadacitinib Chemical Structure

Upadacitinib Chemical Structure

CAS No. : 1310726-60-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 390 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
200 mg USD 850 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
1 g USD 2000 In-stock
Estimated Time of Arrival: December 31
5 g USD 5000 Get quote
10 g USD 8000 Get quote
50 g   Get quote  

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View All JAK Isoform Specific Products:

  • Biological Activity

  • Technical Information

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  • References

Description

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM.

IC50 & Target

IC50: 43 nM (JAK1), 200 nM (JAK2)[1]

In Vitro

In biochemical assays, Upadacitinib is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1]. . The enhanced selectivity of Upadacitinib for JAK-1 over JAK-2 and JAK-3 may offer an improved benefit–risk profile in patients with RA range[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 22 mg/mL (57.84 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6290 mL 13.1451 mL 26.2902 mL
5 mM 0.5258 mL 2.6290 mL 5.2580 mL
10 mM 0.2629 mL 1.3145 mL 2.6290 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

380.37

Formula

C₁₇H₁₉F₃N₆O

CAS No.

1310726-60-3

SMILES

O=C(N1C[[email protected]@H](CC)[[email protected]@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.40%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Upadacitinib
Cat. No.:
HY-19569
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Upadacitinib

Cat. No.: HY-19569