1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Upadacitinib (Synonyms: ABT-494)

Cat. No.: HY-19569 Purity: 99.40%
Data Sheet SDS Handling Instructions

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM.

For research use only. We do not sell to patients.
Upadacitinib Chemical Structure

Upadacitinib Chemical Structure

CAS No. : 1310726-60-3

Size Price Stock Quantity
1 mg $150 In-stock
5 mg $450 Get quote
10 mg $650 Get quote
25 mg $1350 Get quote
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Featured Recommendations

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM.

IC50 & Target

IC50: 43 nM (JAK1), 200 nM (JAK2)[1]

In Vitro

In biochemical assays, Upadacitinib is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance). The enhanced selectivity of Upadacitinib for JAK-1 over JAK-2 and JAK-3 may offer an improved benefit–risk profile in patients with RA range[2].

In Vivo

AbbVie’s second JAK inhibitor in development Upadacitinib has been described as a second-generation inhibitor. Multiple-dose Phase I studies are completed in 2013[1]. In phase I trials, Upadacitinib is found to be safe and well-tolerated up to multiple doses of 24 mg twice daily using the immediate release formulation. Upadacitinib exposure is dose proportional in the evaluated multiple dose[2].

Clinical Trial
View MoreCollapse
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6290 mL 13.1451 mL 26.2902 mL
5 mM 0.5258 mL 2.6290 mL 5.2580 mL
10 mM 0.2629 mL 1.3145 mL 2.6290 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

380.37

Formula

C₁₇H₁₉F₃N₆O

CAS No.

1310726-60-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 22 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Upadacitinib
Cat. No.:
HY-19569
Quantity: