Soficitinib
Based on 1 Customer Validation
Soficitinib (Compound 20) is a selective tyrosine kinase 2 (TYK2) and Janus kinase 2 (JAK2) inhibitor, with IC50 values of 0.5 nM and 1.2 nM, respectively. Soficitinib shows promise for research into autoimmune diseases (such as psoriasis, rheumatoid arthritis) and inflammatory diseases.
For research use only. We do not sell to patients.
- Purity: 98.54%
- CAS No.: 2574524-67-5
- Formula: C18H21ClN8O
- Molecular Weight:400.87
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK2 1.2 nM (IC50) |
Tyk2 0.5 nM (IC50) |
Soficitinib inhibits TYK2 and JAK2 with IC50 values of 0.5 nM and 1.2 nM, respectively[1].
Soficitinib (24 h) inhibits IL-12-induced IFN-γ secretion in NK92 cells, with an IC50 value of 233 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2574524-67-5
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Appearance Solid
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Molecular Weight 400.87
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Formula C18H21ClN8O
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Color White to off-white
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SMILES
C[C@]12[C@](CN(C2)C(CC#N)=O)([H])CN(C3=NC(NC4=CN(C)N=C4)=NC=C3Cl)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (249.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4946 mL | 12.4729 mL | 24.9457 mL | 62.3644 mL |
| 5 mM | 0.4989 mL | 2.4946 mL | 4.9891 mL | 12.4729 mL | |
| 10 mM | 0.2495 mL | 1.2473 mL | 2.4946 mL | 6.2364 mL | |
| 15 mM | 0.1663 mL | 0.8315 mL | 1.6630 mL | 4.1576 mL | |
| 20 mM | 0.1247 mL | 0.6236 mL | 1.2473 mL | 3.1182 mL | |
| 25 mM | 0.0998 mL | 0.4989 mL | 0.9978 mL | 2.4946 mL | |
| 30 mM | 0.0832 mL | 0.4158 mL | 0.8315 mL | 2.0788 mL | |
| 40 mM | 0.0624 mL | 0.3118 mL | 0.6236 mL | 1.5591 mL | |
| 50 mM | 0.0499 mL | 0.2495 mL | 0.4989 mL | 1.2473 mL | |
| 60 mM | 0.0416 mL | 0.2079 mL | 0.4158 mL | 1.0394 mL | |
| 80 mM | 0.0312 mL | 0.1559 mL | 0.3118 mL | 0.7796 mL | |
| 100 mM | 0.0249 mL | 0.1247 mL | 0.2495 mL | 0.6236 mL |
Soficitinib Related Classifications
HY-177131 Related Classifications
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