JAK1-IN-19
JAK1-IN-19 (Compound 18) is a potent JAK1 inhibitor with IC50s of 0.02, 0.5, 91 and 0.2 nM against JAK1, JAK2, JAK3 and TYK2. JAK1-IN-19 exhibits improved rat and human intrinsic clearance. JAK1-IN-19 can be used for the studies of atopic dermatitis and other autoimmune diseases.
For research use only. We do not sell to patients.
- CAS No.: 2169271-17-2
- Formula: C20H21N7O2
- Molecular Weight:391.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK1 0.02 nM (IC50) |
JAK2 0.5 nM (IC50) |
JAK3 91 nM (IC50) |
Tyk2 0.2 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>60000 nM
Compound: 18
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Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes
Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes
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[PMID: 29156136] |
Chemical Information
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CAS No. 2169271-17-2
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Molecular Weight 391.43
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Formula C20H21N7O2
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SMILES
N#C[C@@H]1[C@H](COCC1)N2N=C(C(C(N)=O)=C2)NC3=CC=C(C4=CN(N=C4)C)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Siu T, et al. The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J Med Chem. 2017 Dec 14;60(23):9676-9690. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK1-IN-19 Related Classifications
HY-178282 Related Classifications
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