2169271-17-2
2169271-17-2
Chemical Structure
JAK1-IN-19
- CAS No.: 2169271-17-2
- Formula:C20H21N7O2
- Molecular Weight:391.43
InChIKey: YAHGUPVIQAEPKI-KDOFPFPSSA-N
SMILES: N#C[C@@H]1[C@H](COCC1)N2N=C(C(C(N)=O)=C2)NC3=CC=C(C4=CN(N=C4)C)C=C3
Biological Activity: JAK1-IN-19 (Compound 18) is a potent JAK1 inhibitor with IC50s of 0.02, 0.5, 91 and 0.2 nM against JAK1, JAK2, JAK3 and TYK2. JAK1-IN-19 exhibits improved rat and human intrinsic clearance. JAK1-IN-19 can be used for the studies of atopic dermatitis and other autoimmune diseases[1].
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JAK1-IN-19 | JAK1-IN-19 (Compound 18) is a potent JAK1 inhibitor with IC50s of 0.02, 0.5, 91 and 0.2 nM against JAK1, JAK2, JAK3 and TYK2. JAK1-IN-19 exhibits improved rat and human intrinsic clearance. JAK1-IN-19 can be used for the studies of atopic dermatitis and other autoimmune diseases. | |||||||||||||||||||||
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References
- [1]. Siu T, et al. The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J Med Chem. 2017 Dec 14;60(23):9676-9690. [Content Brief]
Keywords
