Cat. No.: HY-158142

PROTAC TYK2 degrader-1

Customer Review

Based on 1 Customer Validation

PROTAC TYK2 degrader-1 is a TYK2 PROTAC degrader with a D_max ≥ 60%. PROTAC TYK2 degrader-1 reduces the phosphorylation levels of IFNα-induced STAT1 (Tyr701) and STAT3 (Tyr705) in immune cells. PROTAC TYK2 degrader-1 can be used in research on cancer, inflammatory diseases, etc.
(Pink: Tyk2 ligand (HY-158340); Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

Purity: 99.46%
CAS No.: 2770470-20-5
Formula: C₄₀H₄₁N₁₃O₇
Molecular Weight:815.84

Storage:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

PROTAC TYK2 degrader-1 Chemical Structure

CAS No.: 2770470-20-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

PROTAC TYK2 degrader-1 is a TYK2 PROTAC degrader with a D_max ≥ 60%. PROTAC TYK2 degrader-1 reduces the phosphorylation levels of IFNα-induced STAT1 (Tyr701) and STAT3 (Tyr705) in immune cells. PROTAC TYK2 degrader-1 can be used in research on cancer, inflammatory diseases, etc.^[1] (Pink: Tyk2 ligand (HY-158340); Blue: Cereblon ligand (HY-14658); Black: linker).

IC₅₀ & Target^[1]

Tyk2

STAT3

STAT1

Cereblon

All PROTACs Isoforms :

All JAK Isoforms :

All STAT Isoforms :

In Vitro

PROTAC TYK2 degrader-1 (0.1-1000 nM; 16 h) potently induces ≥60% TYK2 protein degradation in NOMO-1 cells following 16-hour treatment at concentrations of 10 nM and 100 nM^[1].
PROTAC TYK2 degrader-1 (3-30 nM; 16 h) reduces TYK2 protein levels and potently inhibits IFNα-induced phosphorylation of STAT1 and STAT3 in Jurkat cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

NOMO-1
Concentration:

0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time:

16 h
Result:

Concentration-dependently reduced TYK2 protein levels, with ≥ 60% degradation observed at both 10 nM and 100 nM.
Showed a hook effect at higher concentrations.

Western Blot Analysis^[1]

Cell Line:

Jurkat
Concentration:

3 nM, 30 nM
Incubation Time:

16 h
Result:

Concentration-dependently reduced TYK2 protein levels, which correlated with a reduction in IFNα-induced phosphorylation of STAT1 (Tyr701) and STAT3 (Tyr705).

Chemical Information

CAS No. 2770470-20-5
Appearance Solid
Molecular Weight 815.84
Formula C₄₀H₄₁N₁₃O₇
Color Light yellow to yellow
SMILES

CNC(C1=NN=C(C=C1NC2=CC=CC(C3=NN(C=N3)C)=C2OC)NC4=NC=C(C=C4)C(NCCCCCNC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (122.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2257 mL

6.1287 mL

12.2573 mL

5 mM

0.2451 mL

1.2257 mL

2.4515 mL

10 mM

0.1226 mL

0.6129 mL

1.2257 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. JingLiu, et al. Tyrosine kinase 2 (tyk2) degradation compounds and methods of use. US20240059671A1.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2257 mL	6.1287 mL	12.2573 mL	30.6433 mL
	5 mM	0.2451 mL	1.2257 mL	2.4515 mL	6.1287 mL
	10 mM	0.1226 mL	0.6129 mL	1.2257 mL	3.0643 mL
	15 mM	0.0817 mL	0.4086 mL	0.8172 mL	2.0429 mL
	20 mM	0.0613 mL	0.3064 mL	0.6129 mL	1.5322 mL
	25 mM	0.0490 mL	0.2451 mL	0.4903 mL	1.2257 mL
	30 mM	0.0409 mL	0.2043 mL	0.4086 mL	1.0214 mL
	40 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.7661 mL
	50 mM	0.0245 mL	0.1226 mL	0.2451 mL	0.6129 mL
	60 mM	0.0204 mL	0.1021 mL	0.2043 mL	0.5107 mL
	80 mM	0.0153 mL	0.0766 mL	0.1532 mL	0.3830 mL
	100 mM	0.0123 mL	0.0613 mL	0.1226 mL	0.3064 mL

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PROTAC TYK2 degrader-1

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

PROTAC Library

Autoimmune Disease Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All PROTACs Isoforms

All JAK Isoforms

All STAT Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

PROTAC TYK2 degrader-1 Related Classifications

Cat. No.: HY-158142