1. Epigenetics
    Stem Cell/Wnt
    Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. JAK
  3. GLPG0634 analog

GLPG0634 analog 

Cat. No.: HY-13961 Purity: 98.58%
COA Handling Instructions

GLPG0634 analog (Compoun 176) is a broad spectrum JAK inhibitor with IC50 values of <100 nM against JAK1, JAK2 and JAK3.

For research use only. We do not sell to patients.

GLPG0634 analog Chemical Structure

GLPG0634 analog Chemical Structure

CAS No. : 1206101-20-3

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Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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Description

GLPG0634 analog (Compoun 176) is a broad spectrum JAK inhibitor with IC50 values of <100 nM against JAK1, JAK2 and JAK3[1].

IC50 & Target[3]

JAK1

<100 nM (IC50)

JAK2

<100 nM (IC50)

JAK3

<100 nM (IC50)

Tyk2

<100 nM (IC50)

In Vitro

GLPG0634 analog (Compoun 176) inhibits JAK-STAT signaling and OSM/IL-lβ signaling with both EC50 values of 101-500 nM[1].
GLPG0634 analog shows microsomal stability of 76%-100% in rat and human[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

410.43

Formula

C23H18N6O2

CAS No.
SMILES

O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 53 mg/mL (129.13 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4365 mL 12.1823 mL 24.3647 mL
5 mM 0.4873 mL 2.4365 mL 4.8729 mL
10 mM 0.2436 mL 1.2182 mL 2.4365 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
GLPG0634 analog
Cat. No.:
HY-13961
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