1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. GLPG0634 analog

GLPG0634 analog 

Cat. No.: HY-13961 Purity: 98.00%
Handling Instructions

GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents.

For research use only. We do not sell to patients.

GLPG0634 analog Chemical Structure

GLPG0634 analog Chemical Structure

CAS No. : 1206101-20-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 217 In-stock
Estimated Time of Arrival: December 31
2 mg USD 144 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents.

IC50 & Target

JAK3

<100 nM (IC50)

Tyk2

<100 nM (IC50)

Molecular Weight

410.43

Formula

C₂₃H₁₈N₆O₂

CAS No.

1206101-20-3

SMILES

O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 53 mg/mL (129.13 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4365 mL 12.1823 mL 24.3647 mL
5 mM 0.4873 mL 2.4365 mL 4.8729 mL
10 mM 0.2436 mL 1.2182 mL 2.4365 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

GLPG0634 analogJAKJanus kinaseInhibitorinhibitorinhibit

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Product name:
GLPG0634 analog
Cat. No.:
HY-13961
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