JAK3/BTK-IN-6
JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research.
For research use only. We do not sell to patients.
- CAS No.: 2243136-03-8
- Formula: C21H17BF3N5O3
- Molecular Weight:455.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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JAK3 0.4 nM (IC50) |
JAK2 657.9 nM (IC50) |
JAK1 >1000 nM (IC50) |
Tyk2 >1000 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
1.1 μM
Compound: 14h
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Antiproliferative activity against human HEL cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HEL cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 31843459] |
| JeKo-1 | IC50 |
0.5 μM
Compound: 14h
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Antiproliferative activity against human JeKo1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human JeKo1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 31843459] |
| OCI-Ly10 | IC50 |
1 μM
Compound: 14h
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Antiproliferative activity against human OCI-LY10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human OCI-LY10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 31843459] |
| Raji | IC50 |
1.7 μM
Compound: 14h
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Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 31843459] |
| Ramos | IC50 |
0.5 μM
Compound: 14h
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Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 31843459] |
In Vitro
JAK3/BTK-IN-6 (compound 14h) shows antiproliferative activities against hematopoietic cells (Raji, Romas, HEL, Jeko-1, and OCI-LY10), with IC50 values of 1.7, 0.5, 1.1, 0.5, and 1-10, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2243136-03-8
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Molecular Weight 455.20
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Formula C21H17BF3N5O3
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SMILES
C=CC(NC1=CC(NC2=C(C=NC(NC3=CC=C4B(OCC4=C3)O)=N2)C(F)(F)F)=CC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK3/BTK-IN-6 Related Classifications
HY-147754 Related Classifications
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