JAK1-IN-12
JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 μM. And IC50s of 0.423 μM, 0.410 μM and 1.12 μM for JAK2, JAK3 and TYK2. JAK1-IN-12 promotes hair growth in mice. JAK1-IN-12 can be used for research of immune and inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2945204-95-3
- 分子式: C20H23N5O
- 分子量:349.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
JAK1 0.0246 μM (IC50) |
JAK2 0.423 μM (IC50) |
JAK3 0.410 μM (IC50) |
Tyk2 1.12 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| BaF3 | IC50 |
0.11 μM
Compound: 12b
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Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK1 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK1 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
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[PMID: 37163463] |
| BaF3 | IC50 |
6.105 μM
Compound: 12b
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Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK2 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK2 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
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[PMID: 37163463] |
体外実験
HDAC-IN-57 (Compound 12b) inhibits JAK1 and JAK2 activity in Ba/F3-TEL-JAK1 cell lines, with IC50 of 0.110 μM and 6.105 μM[1].
HDAC-IN-57 (Compound 12b) (1 μM) showed strong interaction with JAK1, JAK3, PKD2, HPK1, AurB in vitro panel assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/B6 mice[1]
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Dosage:2% in 10% DMSO solution
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Administration:External use; applied daily for 1 month
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Result:Promoted skin darkening within 9 days and new hair growth within 13 days in shaved area of the dorsal back of C57/B6 mice
化学情報
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CAS 番号 2945204-95-3
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分子量 349.43
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分子式 C20H23N5O
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SMILES
O[C@]12C[C@@H](C[C@H]3C2)[C@H](NC4=C(C=CN5)C5=NC=C4C6=CNN=C6)[C@@H](C3)C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
参考文献
JAK1-IN-12 関連分類
HY-149296 関連分類
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