JAK1-IN-12
JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 μM. And IC50s of 0.423 μM, 0.410 μM and 1.12 μM for JAK2, JAK3 and TYK2. JAK1-IN-12 promotes hair growth in mice. JAK1-IN-12 can be used for research of immune and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 2945204-95-3
- Formula: C20H23N5O
- Molecular Weight:349.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK1 0.0246 μM (IC50) |
JAK2 0.423 μM (IC50) |
JAK3 0.410 μM (IC50) |
Tyk2 1.12 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| BaF3 | IC50 |
0.11 μM
Compound: 12b
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Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK1 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK1 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
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[PMID: 37163463] |
| BaF3 | IC50 |
6.105 μM
Compound: 12b
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Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK2 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK2 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
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[PMID: 37163463] |
HDAC-IN-57 (Compound 12b) inhibits JAK1 and JAK2 activity in Ba/F3-TEL-JAK1 cell lines, with IC50 of 0.110 μM and 6.105 μM[1].
HDAC-IN-57 (Compound 12b) (1 μM) showed strong interaction with JAK1, JAK3, PKD2, HPK1, AurB in vitro panel assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/B6 mice[1]
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Dosage:2% in 10% DMSO solution
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Administration:External use; applied daily for 1 month
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Result:Promoted skin darkening within 9 days and new hair growth within 13 days in shaved area of the dorsal back of C57/B6 mice
Chemical Information
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CAS No. 2945204-95-3
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Molecular Weight 349.43
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Formula C20H23N5O
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SMILES
O[C@]12C[C@@H](C[C@H]3C2)[C@H](NC4=C(C=CN5)C5=NC=C4C6=CNN=C6)[C@@H](C3)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK1-IN-12 Related Classifications
HY-149296 Related Classifications
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