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Cat. No.: HY-401428

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TYK2 ligand 3

TYK2 ligand 3 is a TYK2 ligand that can be used for the synthesis of PROTACs, such as PROTAC TYK2 degrader-2 (HY-152227).

For research use only. We do not sell to patients.

CAS No.: 2921556-43-4
Formula: C₂₃H₂₂N₈O₄
Molecular Weight:474.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TYK2 ligand 3 Chemical Structure

CAS No.: 2921556-43-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

TYK2 ligand 3 is a TYK2 ligand that can be used for the synthesis of PROTACs, such as PROTAC TYK2 degrader-2 (HY-152227)^[1].

IC₅₀ & Target^[1]

Tyk2

All JAK Isoforms :

Chemical Information

CAS No. 2921556-43-4
Molecular Weight 474.47
Formula C₂₃H₂₂N₈O₄
SMILES

CNC(C1=CN=C(C=C1NC2=C(C(C3=NN(C=N3)C)=CC=C2)OC)NC4=CC=C(C=N4)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jun-Ya Kato, et al. Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor. Bioorg Med Chem Lett. 2023 Jan 1;79:129083. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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TYK2 ligand 3

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TYK2 ligand 3 Related Classifications

HY-401428 Related Classifications