PROTAC TYK2 degrader-2
Based on 1 Customer Validation
PROTAC TYK2 degrader-2 is a potent and subtype-selective TYK2 degrader. PROTAC TYK2 degrader-2 has TYK2 degradation activity with DC50 value of 14 nM. PROTAC TYK2 degrader-2 can be used for the research of autoimmune disease.
(Pink: Tyk2 ligand (HY-401428); Blue: VHL ligand (HY-125845); Black: linker (HY-W105744)).
For research use only. We do not sell to patients.
- Purity: 99.23%
- CAS No.: 2921556-14-9
- Formula: C55H69N13O7S
- Molecular Weight:1056.28
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
DC50: 14 nM (TYK2)[1]
PROTAC TYK2 degrader-2 (degrader 37) (1 µM; 6 h) selectively suppresses TYK2 protein levels[1].
PROTAC TYK2 degrader-2 has TYK2 degradation activity with DC50 value of 14 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:1 µM
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Incubation Time:6 h
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Result:Suppressed TYK2 protein levels and effectively induced the degradation of TYK2 in a dose-dependent manner at a low concentration range, with TYK2 degradation slightly decreasing at high concentrations.
Chemical Information
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CAS No. 2921556-14-9
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Appearance Solid
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Molecular Weight 1056.28
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Formula C55H69N13O7S
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Color Off-white to light yellow
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SMILES
CNC(C1=CN=C(C=C1NC2=C(C(C3=NN(C=N3)C)=CC=C2)OC)NC4=CC=C(C=N4)C(NCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 10 mg/mL (9.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9467 mL | 4.7336 mL | 9.4672 mL | 23.6680 mL |
| 5 mM | 0.1893 mL | 0.9467 mL | 1.8934 mL | 4.7336 mL |
PROTAC TYK2 degrader-2 Related Classifications
HY-152227 Related Classifications
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