PROTAC TYK2 degrader-2 

PROTAC TYK2 degrader-2 is a potent and subtype-selective TYK2 degrader. PROTAC TYK2 degrader-2 has TYK2 degradation activity with DC₅₀ value of 14 nM. PROTAC TYK2 degrader-2 can be used for the research of autoimmune disease^[1]. (Pink: Tyk2 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker (HY-W105744)).

DC50: 14 nM (TYK2)^[1]

PROTAC TYK2 degrader-2 (degrader 37) (1 µM; 6 h) selectively suppresses TYK2 protein levels^[1].
PROTAC TYK2 degrader-2 has TYK2 degradation activity with DC₅₀ value of 14 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1056.28

C₅₅H₆₉N₁₃O₇S

2921556-14-9

Solid

Off-white to light yellow

CNC(C1=CN=C(C=C1NC2=C(C(C3=NN(C=N3)C)=CC=C2)OC)NC4=CC=C(C=N4)C(NCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Jun-Ya Kato, et al. Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor. Bioorg Med Chem Lett. 2023 Jan 1;79:129083.  [Content Brief]