JAK-IN-38
JAK-IN-38 (Compound 1) is a JAK inhibitor, with IC50s of 0.03, 0.06, 0.12, 0.44 μM for Tyk2, JAK3, JAK2, JAK1 respectively. JAK-IN-38 is a collagen VII (C7) inducer and has anti-inflammatory activity. JAK-IN-38 can upregulate the expression of COL7A1 mRNA in donor-derived keratinocytes and works together with Gentamicin (HY-A0276A) to boost overall C7 levels.
For research use only. We do not sell to patients.
- Formula: C25H28N6O3
- Molecular Weight:460.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Tyk2 0.03 μM (IC50) |
JAK3 0.06 μM (IC50) |
JAK2 0.12 μM (IC50) |
JAK1 0.44 μM (IC50) |
In Vitro
Collagen VII (C7) is a major collagen component of anchoring fibers encoded by the COL7A1 gene. It forms anchoring fibers at the epidermal-dermal junction, anchoring the epidermal basement membrane to the dermis and maintaining skin structural integrity. COL7A1 mutations lead to epidermolysis bullosa, and downregulation of C7 protein levels is associated with skin aging. Regulation of COL7A1 expression is an important target for research on skin regeneration, wound healing, and anti-aging.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 460.53
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Formula C25H28N6O3
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SMILES
[H][C@@]1(C2CC3CC1C[C@@](C3)(C2)O)NC(C4=C(N=CC(C5=CC=C6C=CN(C6=C5)CC(N)=O)=N4)N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK-IN-38 Related Classifications
HY-162862 Related Classifications
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