Tyk2-IN-26
Tyk2-IN-26 (compound 18) is a TYK2 inhibitor that suppresses TYK2/STAT signaling induced by IL-23 and IFNα, with IC50 values all below 30 nM. Tyk2-IN-26 is applicable to research related to TYK2, IL-23, type I IFN signaling, as well as inflammatory immunity.
For research use only. We do not sell to patients.
- CAS No.: 2824164-06-7
- Formula: C23H25N7O2
- Molecular Weight:431.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Tyk2 |
Pretreatment with Tyk2-IN-26 (compound 18) for 60 min inhibits IL-23 (10 ng/mL; 22-24 h)-induced STAT3-dependent SEAP reporter gene activity, with an IC50 of <30 nM[1].
Tyk2-IN-26 exhibits only weak or no significant inhibitory effect on SEAP reporter gene responses induced by IL-2 (4 ng/mL; 24 h) and IFNγ (50 ng/mL; 24 h), with IC50 values >1000 nM for both pathways[1].
Tyk2-IN-26 exhibits an IC50 of >1000 nM against recombinant TYK2-JH1, JAK1-JH1 and JAK2-JH1 in HTRF kinase assays, while its IC50 against JAK3-JH1 ranges from 30 to 300 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2824164-06-7
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Molecular Weight 431.49
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Formula C23H25N7O2
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SMILES
O=C(C1=CN=C(NC(C2CC2)=O)C=C1NC3=CC=CC4=C3N(C)CC5=CN(C)N=C45)NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyk2-IN-26 Related Classifications
HY-184866 Related Classifications
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