1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
    Cell Cycle/DNA Damage
  2. JAK
    HDAC
  3. JAK/HDAC-IN-1

JAK/HDAC-IN-1 

Cat. No.: HY-126141
Handling Instructions

JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively.

For research use only. We do not sell to patients.

JAK/HDAC-IN-1 Chemical Structure

JAK/HDAC-IN-1 Chemical Structure

CAS No. : 2284621-75-4

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Description

JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1].

IC50 & Target[1]

JAK2

4 nM (IC50)

JAK1

4.8 nM (IC50)

JAK3

7.4 nM (IC50)

Tyk2

49 nM (IC50)

HDAC

2 nM (IC50)

HDAC2

14 nM (IC50)

HDAC6

120 nM (IC50)

HDAC8

2470 nM (IC50)

In Vitro

JAK/HDAC-IN-1 (Compound 8m) exhibits IC50s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

450.32

Formula

C₁₉H₂₁Cl₂N₇O₂

CAS No.

2284621-75-4

SMILES

ClC1=CC=C(NC2=NC(NC3=CN(CCCCCC(NO)=O)N=C3)=NC=C2Cl)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
JAK/HDAC-IN-1
Cat. No.:
HY-126141
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JAK/HDAC-IN-1

Cat. No.: HY-126141