2284621-75-4
2284621-75-4
Chemical Structure
JAK/HDAC-IN-1
- CAS No.: 2284621-75-4
- Formula:C19H21Cl2N7O2
- Molecular Weight:450.32
IUPAC Name: 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexanamide
InChIKey: MTOQNLGMTJOJOF-UHFFFAOYSA-N
SMILES: ClC1=CC=C(NC2=NC(NC3=CN(CCCCCC(NO)=O)N=C3)=NC=C2Cl)C=C1
Biological Activity: JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1].
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JAK/HDAC-IN-1 | 98.63% | JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively. | ||||||||||||||||||||
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