2. PI3K/Akt/mTOR
  3. Akt
  4. CTX-0294885

CTX-0294885 

Cat. No.: HY-15985 Purity: 98.44%
COA Handling Instructions

CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer.

For research use only. We do not sell to patients.

CTX-0294885 Chemical Structure

CTX-0294885 Chemical Structure

CAS No. : 1439934-41-4

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 131 In-stock
Solution
10 mM * 1 mL in DMSO USD 131 In-stock
Solid
5 mg USD 119 In-stock
10 mg USD 198 In-stock
50 mg USD 594 In-stock
100 mg USD 858 In-stock
200 mg USD 1518 In-stock
500 mg   Get quote  
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of CTX-0294885:

CTX-0294885 Related Antibodies

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Akt Akt1 Akt2 Akt3

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Description

CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer[1].

In Vitro

CTX-0294885 is a kinase capture tool in large-scale kinome profiling experiments, with 185 kinases identified as total protein, and 179 identified from TiO2 enrichment for phosphopeptides in MDA-MB-231 cells (by quantitative MS)[1].
CTX-0294885 captures all members of the AKT family that is not identified from previous studies using other kinase capture reagents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CTX-0294885 Related Antibodies
Molecular Weight

437.93

Appearance

Solid

Formula

C22H24ClN7O
CAS No.
SMILES

O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCNCC4)C=C3)=NC=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (228.35 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2835 mL 11.4173 mL 22.8347 mL
5 mM 0.4567 mL 2.2835 mL 4.5669 mL
10 mM 0.2283 mL 1.1417 mL 2.2835 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.71 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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CTX-0294885 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

Keywords:

CTX-02948851439934-41-4CTX0294885CTX 0294885AktPKBProtein kinase BAKTcancerkinome profilingMDA-MB-231inflammationdiabetesInhibitorinhibitorinhibit

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