2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR Ack1
  4. EGFR/ACK1-IN-1

EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity.

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EGFR/ACK1-IN-1

EGFR/ACK1-IN-1 화학구조

CAS No. : 3032642-29-5

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EGFR/ACK1-IN-1 Related Antibodies

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제품 설명

EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
1.27 μM
Compound: 21a
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 38323982]
NCI-H1975 IC50
1.04 μM
Compound: 21a
Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
[PMID: 38323982]
분자량

433.89

화학식

C22H20ClN7O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=CC=C(C2=C1)N=C(N=C2NC3=CC=CC(NC(C=C)=O)=C3)NC4=CN(N=C4)CC
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
순도&문서
References
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EGFR/ACK1-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/ACK1-IN-13032642-29-5EGFRAck1Epidermal growth factor receptorErbB-1HER1Activated Cdc42 kinase 1TNK2ACK1InhibitorMCF-7AZDRAntitumorinhibitorinhibit

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상품명:
EGFR/ACK1-IN-1
Cat. No.:
HY-162254
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