SM1-71-R
Based on 1 Customer Validation
SM1-71-R is a reversible analog o SM1-71 (HY-136848). SM1-71-R lacks the acrylamide warhead and therefore cannot form a covalent bond with the kinase. SM1-71-R can be used as a control compound for SM1-71.
For research use only. We do not sell to patients.
- Purity: 98.7%
- CAS No.: 2088180-03-2
- Formula: C24H28ClN7O
- Molecular Weight:465.98
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| ASPC1 | IC50 |
73 nM
Compound: 9
|
Antiproliferative activity against human AsPC1 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human AsPC1 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay
|
[PMID: 28038940] |
| BaF3 | IC50 |
5 nM
Compound: 9
|
Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay
|
[PMID: 28038940] |
| BaF3 | IC50 |
8 nM
Compound: 9
|
Antiproliferative activity against mouse BA/F3 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse BA/F3 cells after 72 hrs by CellTiter-Glo assay
|
[PMID: 28038940] |
| BaF3 | IC50 |
9 nM
Compound: 9
|
Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs in presence of IL-3 by CellTiter-Glo assay
Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs in presence of IL-3 by CellTiter-Glo assay
|
[PMID: 28038940] |
| PANC-1 | IC50 |
426 nM
Compound: 9
|
Antiproliferative activity against human PANC1 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human PANC1 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay
|
[PMID: 28038940] |
| SK-CO-1 | IC50 |
54 nM
Compound: 9
|
Antiproliferative activity against human SKCO1 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human SKCO1 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay
|
[PMID: 28038940] |
| SW-620 | IC50 |
247 nM
Compound: 9
|
Antiproliferative activity against human SW620 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human SW620 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay
|
[PMID: 28038940] |
SM1-71-R (1 μM; 2 h) results in inhibition of phosphorylation of p-AKTS473 in H23-KRASG12C cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H23-KRASG12C cells
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Concentration:1 μM
-
Incubation Time:2 h
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Result:Resulted in inhibition of phosphorylation of only p-AKTS473, did not inhibit phosphorylation on p-ERK1/2T202/Y204 and p-MEK1/2S217/S221 levels.
Chemical Information
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CAS No. 2088180-03-2
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Appearance Solid
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Molecular Weight 465.98
-
Formula C24H28ClN7O
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SMILES
O=C(CC)NC1=C(C=CC=C1)NC2=NC(NC3=CC=C(N(CC4)CCN4C)C=C3)=NC=C2Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)