1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR-IN-55

EGFR-IN-55 

Cat. No.: HY-146132
Handling Instructions

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity.

For research use only. We do not sell to patients.

EGFR-IN-55 Chemical Structure

EGFR-IN-55 Chemical Structure

CAS No. : 2057423-46-6

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Description

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].

IC50 & Target

EGFRL858R/T790M

3.9 nM (IC50)

EGFRWT

70 nM (IC50)

Molecular Weight

526.42

Formula

C25H25Cl2N7O2

CAS No.
SMILES

C=C(Cl)C(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3)=NC=C2Cl)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EGFR-IN-55
Cat. No.:
HY-146132
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