2057423-46-6
2057423-46-6
Chemical Structure
EGFR-IN-55
- CAS No.: 2057423-46-6
- Formula:C25H25Cl2N7O2
- Molecular Weight:526.42
IUPAC Name: N-(3-((2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)phenyl)-2-chloroacrylamide
InChIKey: IKFWHIAKKGOESN-UHFFFAOYSA-N
SMILES: C=C(Cl)C(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3)=NC=C2Cl)=C1)=O
Biological Activity: EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].
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EGFR-IN-55 | EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity. | |||||||||||||||||||||
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References
Keywords
