2. PF-06263276

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.

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PF-06263276 Chemical Structure

PF-06263276 Chemical Structure

CAS No. : 1421502-62-6

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Description

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].

IC50 & Target

IC50：2.2 nM (JAK1), 23.1 nM (JAK2), 59.9 nM (JAK3), 29.7 nM (TYK2)[1]
Clinical Trial
Molecular Weight

566.63

Formula

C31H31FN8O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CN(C(C6=NC=C(N7CCCCC7)N=C6)=O)CC5)N4)=C3C=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (58.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7648 mL 8.8241 mL 17.6482 mL
5 mM 0.3530 mL 1.7648 mL 3.5296 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.38%

COA (251 KB) HNMR (125 KB) RP-HPLC (155 KB) LCMS (374 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7648 mL 8.8241 mL 17.6482 mL 44.1205 mL
5 mM 0.3530 mL 1.7648 mL 3.5296 mL 8.8241 mL
10 mM 0.1765 mL 0.8824 mL 1.7648 mL 4.4121 mL
15 mM 0.1177 mL 0.5883 mL 1.1765 mL 2.9414 mL
20 mM 0.0882 mL 0.4412 mL 0.8824 mL 2.2060 mL
25 mM 0.0706 mL 0.3530 mL 0.7059 mL 1.7648 mL
30 mM 0.0588 mL 0.2941 mL 0.5883 mL 1.4707 mL
40 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1030 mL
50 mM 0.0353 mL 0.1765 mL 0.3530 mL 0.8824 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-062632761421502-62-6PF06263276PF 06263276Inhibitorinhibitorinhibit

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