1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. PF-06263276

PF-06263276 

Cat. No.: HY-101024
Handling Instructions

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.

For research use only. We do not sell to patients.

PF-06263276 Chemical Structure

PF-06263276 Chemical Structure

CAS No. : 1421502-62-6

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Description

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].

IC50 & Target[1]

JAK1

2.2 nM (IC50)

JAK2

23.1 nM (IC50)

JAK3

59.9 nM (IC50)

Tyk2

29.7 nM (IC50)

Clinical Trial
Molecular Weight

566.63

Formula

C₃₁H₃₁FN₈O₂

CAS No.

1421502-62-6

SMILES

FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CN(C(C6=NC=C(N7CCCCC7)N=C6)=O)CC5)N4)=C3C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PF-06263276
Cat. No.:
HY-101024
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