1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. PF-06263276

PF-06263276 

Cat. No.: HY-101024 Purity: >99.0%
Handling Instructions

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.

For research use only. We do not sell to patients.

PF-06263276 Chemical Structure

PF-06263276 Chemical Structure

CAS No. : 1421502-62-6

Size Price Stock Quantity
1 mg USD 195 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Description

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].

IC50 & Target[1]

JAK1

2.2 nM (IC50)

JAK2

23.1 nM (IC50)

JAK3

59.9 nM (IC50)

Tyk2

29.7 nM (IC50)

Clinical Trial
Molecular Weight

566.63

Formula

C₃₁H₃₁FN₈O₂

CAS No.

1421502-62-6

SMILES

FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CN(C(C6=NC=C(N7CCCCC7)N=C6)=O)CC5)N4)=C3C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

PF-06263276PF06263276PF 06263276JAKJanus kinaseInhibitorinhibitorinhibit

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Product Name:
PF-06263276
Cat. No.:
HY-101024
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