1. Epigenetics
    Stem Cell/Wnt
    Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. JAK
  3. TCJL37

TCJL37 

Cat. No.: HY-16640
Handling Instructions

TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).

For research use only. We do not sell to patients.

TCJL37 Chemical Structure

TCJL37 Chemical Structure

CAS No. : 1258294-34-6

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Description

TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD)[1].

IC50 & Target[1]

Tyk2

1.6 nM (Ki)

In Vitro

In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.74

Formula

C17H11ClF2N4O2

CAS No.
SMILES

O=C(NC1=CC(NC([[email protected]@H]2[[email protected]](F)C2)=O)=NC=C1)C3=C(F)C=C(C#N)C=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TCJL37
Cat. No.:
HY-16640
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