TCJL37
Based on 1 Customer Validation
TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.89%
- CAS. Nr.: 1258294-34-6
- Formel: C17H11ClF2N4O2
- Molecular Weight:376.74
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Momelotinib (Standard)JAK1/2 Inhibitor
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Tyk2 1.6 nM (Ki) |
In Vitro
In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1258294-34-6
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Appearance Solid
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Molecular Weight 376.74
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Formel C17H11ClF2N4O2
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Color Light yellow to light brown
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SMILES
O=C(NC1=CC(NC([C@@H]2[C@H](F)C2)=O)=NC=C1)C3=C(F)C=C(C#N)C=C3Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 175 mg/mL (464.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6544 mL | 13.2718 mL | 26.5435 mL | 66.3588 mL |
| 5 mM | 0.5309 mL | 2.6544 mL | 5.3087 mL | 13.2718 mL | |
| 10 mM | 0.2654 mL | 1.3272 mL | 2.6544 mL | 6.6359 mL | |
| 15 mM | 0.1770 mL | 0.8848 mL | 1.7696 mL | 4.4239 mL | |
| 20 mM | 0.1327 mL | 0.6636 mL | 1.3272 mL | 3.3179 mL | |
| 25 mM | 0.1062 mL | 0.5309 mL | 1.0617 mL | 2.6544 mL | |
| 30 mM | 0.0885 mL | 0.4424 mL | 0.8848 mL | 2.2120 mL | |
| 40 mM | 0.0664 mL | 0.3318 mL | 0.6636 mL | 1.6590 mL | |
| 50 mM | 0.0531 mL | 0.2654 mL | 0.5309 mL | 1.3272 mL | |
| 60 mM | 0.0442 mL | 0.2212 mL | 0.4424 mL | 1.1060 mL | |
| 80 mM | 0.0332 mL | 0.1659 mL | 0.3318 mL | 0.8295 mL | |
| 100 mM | 0.0265 mL | 0.1327 mL | 0.2654 mL | 0.6636 mL |
TCJL37 Related Classifications
HY-16640 Related Classifications
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