TCJL37
Based on 1 Customer Validation
TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 1258294-34-6
- Formula: C17H11ClF2N4O2
- Molecular Weight:376.74
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
HY-L001
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Epigenetics Compound Library
HY-L005
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Immunology/Inflammation Compound Library
HY-L007
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JAK/STAT Compound Library
HY-L008
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
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Stem Cell Signaling Compound Library
HY-L017
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Anti-Aging Compound Library
HY-L034
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Differentiation Inducing Compound Library
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Reprogramming Compound Library
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Orally Active Compound Library
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Anti-Breast Cancer Compound Library
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Anti-Lung Cancer Compound Library
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Anti-Pancreatic Cancer Compound Library
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Anti-Blood Cancer Compound Library
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Anti-Obesity Compound Library
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Anti-Liver Cancer Compound Library
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Anti-Prostate Cancer Compound Library
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Cancer Stem Cells Compound Library
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Heterocyclic Compound Library
HY-L138
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Autoimmune Disease Compound Library
HY-L156
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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MCE Bioactive Compound Library
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Protein Kinase Compound Library
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High-Throughput Bioactive Compound Library
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Anti-Rheumatic Arthritis Compound Library
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Posttranslational Modification Library
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Biological Activity
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Tyk2 1.6 nM (Ki) |
In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1258294-34-6
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Appearance Solid
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Molecular Weight 376.74
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Formula C17H11ClF2N4O2
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Color Light yellow to light brown
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SMILES
O=C(NC1=CC(NC([C@@H]2[C@H](F)C2)=O)=NC=C1)C3=C(F)C=C(C#N)C=C3Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 175 mg/mL (464.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.6544 mL | 13.2718 mL | 26.5435 mL | 66.3588 mL |
| 5 mM | 0.5309 mL | 2.6544 mL | 5.3087 mL | 13.2718 mL | |
| 10 mM | 0.2654 mL | 1.3272 mL | 2.6544 mL | 6.6359 mL | |
| 15 mM | 0.1770 mL | 0.8848 mL | 1.7696 mL | 4.4239 mL | |
| 20 mM | 0.1327 mL | 0.6636 mL | 1.3272 mL | 3.3179 mL | |
| 25 mM | 0.1062 mL | 0.5309 mL | 1.0617 mL | 2.6544 mL | |
| 30 mM | 0.0885 mL | 0.4424 mL | 0.8848 mL | 2.2120 mL | |
| 40 mM | 0.0664 mL | 0.3318 mL | 0.6636 mL | 1.6590 mL | |
| 50 mM | 0.0531 mL | 0.2654 mL | 0.5309 mL | 1.3272 mL | |
| 60 mM | 0.0442 mL | 0.2212 mL | 0.4424 mL | 1.1060 mL | |
| 80 mM | 0.0332 mL | 0.1659 mL | 0.3318 mL | 0.8295 mL | |
| 100 mM | 0.0265 mL | 0.1327 mL | 0.2654 mL | 0.6636 mL |
TCJL37 Related Classifications
HY-16640 Related Classifications
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