JAK-IN-21
Based on 1 publication(s) in Google Scholar
JAK-IN-21 (Example 4) is a selective and potent JAK inhibitor with IC50s of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 2445499-20-5
- Formula: C19H16N8O
- Molecular Weight:372.38
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) JAK-IN-21
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Biological Activity
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JAK1 1.73 nM (IC50) |
JAK2 2.04 nM (IC50) |
Tyk2 62.9 nM (IC50) |
JAK2-V617F 109 nM (IC50) |
JAK-IN-21 (Example 4) doses not inhibit CYPs and shows good liver microsome stability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats[1]
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Dosage:10 mg/kg
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Administration:Oral gavage (Pharmacokinetic Study)
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Result:Rat Colon Pharmacokinetic Study[1]
Compound Plasma Cmax
(ng/mL)Plasma AUC
(h*ng/mL)t1/2 (h) Colon AUC
(h*ng/g)Colon + Feces AUC
(h*ng/g)JAK-IN-21 68.8 96 1.6 6,623 545,501
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Animal Model:SD rats[1]
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Dosage:1 mg/kg or 2 mg/kg
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Administration:Intravenous injection (1 mg/kg) or oral gavage (2 mg/kg) (Pharmacokinetic Study)
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Result:Pharmacokinetic Parameters in Sprague-Dawley Rats by Intravenous Administration and Oral Administration[1]
Compound Dose
(mg/kg)AUC
(h*ng/mL)T1/2 (h) Cl
(mL/min/kg)Vd
(L/kg)Cmax
(ng/mL)F (%) JAK-IN-21 (iv) 1 854.8 0.22 19.4 0.37 JAK-IN-21 (ig) 2 29.8 0.38 40.4 1.9
Chemical Information
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CAS No. 2445499-20-5
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Appearance Solid
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Molecular Weight 372.38
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Formula C19H16N8O
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Color Light yellow to yellow
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SMILES
N#CCNC(C1=CC=C(C2=NC(NC3=CN(CC#N)N=C3)=NC=C2C)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced inflammation via the 67LR/JAK2/STAT3 signaling pathway. [Abstract]2025 Nov 28;15(1):42738. PMID: 41315587
Solvent & Solubility
DMSO : 125 mg/mL (335.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6854 mL | 13.4271 mL | 26.8543 mL | 67.1357 mL |
| 5 mM | 0.5371 mL | 2.6854 mL | 5.3709 mL | 13.4271 mL | |
| 10 mM | 0.2685 mL | 1.3427 mL | 2.6854 mL | 6.7136 mL | |
| 15 mM | 0.1790 mL | 0.8951 mL | 1.7903 mL | 4.4757 mL | |
| 20 mM | 0.1343 mL | 0.6714 mL | 1.3427 mL | 3.3568 mL | |
| 25 mM | 0.1074 mL | 0.5371 mL | 1.0742 mL | 2.6854 mL | |
| 30 mM | 0.0895 mL | 0.4476 mL | 0.8951 mL | 2.2379 mL | |
| 40 mM | 0.0671 mL | 0.3357 mL | 0.6714 mL | 1.6784 mL | |
| 50 mM | 0.0537 mL | 0.2685 mL | 0.5371 mL | 1.3427 mL | |
| 60 mM | 0.0448 mL | 0.2238 mL | 0.4476 mL | 1.1189 mL | |
| 80 mM | 0.0336 mL | 0.1678 mL | 0.3357 mL | 0.8392 mL | |
| 100 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.6714 mL |
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