Tyk2-IN-22
Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation.
For research use only. We do not sell to patients.
- CAS No.: 933667-23-3
- Formula: C16H16ClN5O2
- Molecular Weight:345.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Tyk2 9.7 nM (IC50) |
JAK1 148.6 nM (IC50) |
JAK3 883.3 nM (IC50) |
Chemical Information
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CAS No. 933667-23-3
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Molecular Weight 345.78
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Formula C16H16ClN5O2
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SMILES
O=C1N2C(NC(C3=CC=C(Cl)C=C3)=N2)=NC(CN4CCOCC4)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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