933667-23-3
933667-23-3
Chemical Structure
Tyk2-IN-22
- CAS No.: 933667-23-3
- Formula:C16H16ClN5O2
- Molecular Weight:345.78
InChIKey: RZMOUUKYNPBBBH-UHFFFAOYSA-N
SMILES: O=C1N2C(NC(C3=CC=C(Cl)C=C3)=N2)=NC(CN4CCOCC4)=C1
Biological Activity: Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation[1].
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Tyk2-IN-22 | Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation. | |||||||||||||||||||||
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References
Keywords
