1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Decernotinib (Synonyms: VX-509; VRT-831509)

Cat. No.: HY-12469 Purity: 99.12%
Data Sheet SDS Handling Instructions

Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.

For research use only. We do not sell to patients.
Decernotinib Chemical Structure

Decernotinib Chemical Structure

CAS No. : 944842-54-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO $78 In-stock
2 mg $60 In-stock
5 mg $90 In-stock
10 mg $150 In-stock
25 mg $270 In-stock
50 mg $500 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Featured Recommendations

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. IC50 value: 2.5 nM(Ki) [1] Target: JAK3 in vitro: VX-509 potently inhibits JAK3 in enzyme assays (Ki =2.5 nM + 0.7 nM) and cellular assays dependent on JAK3 activity (IC50 range, 50-170 nM), with limited or no measurable potency against other JAK isotypes or non-JAK kinases [1]. in vivo: VX-509 also showed activity in two animal models of aberrant immune function. VX-509 treatment resulted in dose-dependent reduction in ankle swelling and paw weight and improved paw histopathology scores in the rat collagen-induced arthritis (CIA) model. In a mouse model of oxazolone-induced delayed-type hypersensitivity (DTH), VX-509 reduced the T-cell-mediated inflammatory response in skin [1].

Clinical Trial
View MoreCollapse
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.5485 mL 12.7427 mL 25.4855 mL
5 mM 0.5097 mL 2.5485 mL 5.0971 mL
10 mM 0.2549 mL 1.2743 mL 2.5485 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

392.38

Formula

C₁₈H₁₉F₃N₆O

CAS No.

944842-54-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Decernotinib
Cat. No.:
HY-12469
Quantity: