1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Decernotinib (Synonyms: VX-509; VRT-831509)

Cat. No.: HY-12469 Purity: 99.12%
Data Sheet SDS Handling Instructions

Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.

For research use only. We do not sell to patients.
Decernotinib Chemical Structure

Decernotinib Chemical Structure

CAS No. : 944842-54-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 93 In-stock
2 mg USD 72 In-stock
5 mg USD 108 In-stock
10 mg USD 180 In-stock
25 mg USD 324 In-stock
50 mg USD 600 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

    Decernotinib purchased from MCE. Usage Cited in: Science. 2017 Dec 1;358(6367). pii: eaan4368.

    Kinobead western Blot readout for selected inhibitor:protein combinations.

    Decernotinib purchased from MCE. Usage Cited in: Science. 2017 Dec 1;358(6367). pii: eaan4368.

    Immunoblot analysis in MV-4-11 cells and MOLM-13, FLT3-WT and FLT3-ITD transfected HEK293 cells, and Ba/F3 FLT3-ITD cells revealed FLT3 target engagement for Golvatinib and Cabozantinib.

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    Description

    Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. IC50 value: 2.5 nM(Ki) [1] Target: JAK3 in vitro: VX-509 potently inhibits JAK3 in enzyme assays (Ki =2.5 nM + 0.7 nM) and cellular assays dependent on JAK3 activity (IC50 range, 50-170 nM), with limited or no measurable potency against other JAK isotypes or non-JAK kinases [1]. in vivo: VX-509 also showed activity in two animal models of aberrant immune function. VX-509 treatment resulted in dose-dependent reduction in ankle swelling and paw weight and improved paw histopathology scores in the rat collagen-induced arthritis (CIA) model. In a mouse model of oxazolone-induced delayed-type hypersensitivity (DTH), VX-509 reduced the T-cell-mediated inflammatory response in skin [1].

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    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.5485 mL 12.7427 mL 25.4855 mL
    5 mM 0.5097 mL 2.5485 mL 5.0971 mL
    10 mM 0.2549 mL 1.2743 mL 2.5485 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    392.38

    Formula

    C₁₈H₁₉F₃N₆O

    CAS No.

    944842-54-0

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    Decernotinib
    Cat. No.:
    HY-12469
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