JAK1-IN-18
JAK1-IN-18 (Example 2) is a selective JAK1 inhibitor with an IC50 of 0.15 nM for JAK1 over JAK2 and JAK3. JAK1-IN-18 significantly reduces inflammation in DSS (HY-116282C)-induced ulcerative colitis (UC) mouse models and DNBS(HY-W324435)-induced Crohn's disease (CD) rat models. JAK1-IN-18 can be used for autoimmune diseases (such as inflammatory bowel disease), viral infections (such as HBV infection) and cancers (such as blood cancer) research.
For research use only. We do not sell to patients.
- CAS No.: 2459377-98-9
- Formula: C16H20F2N6O2
- Molecular Weight:366.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK1 0.15 nM (IC50) |
JAK2 3.69 nM (IC50) |
JAK3 3.10 nM (IC50) |
Tyk2 1.49 nM (IC50) |
Chemical Information
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CAS No. 2459377-98-9
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Molecular Weight 366.37
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Formula C16H20F2N6O2
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SMILES
O=C(NCC(F)F)[C@@H]1CN(CCC1)NC2=C3C(NC=C3)=NC=C2C(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK1-IN-18 Related Classifications
HY-176793 Related Classifications
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