2459377-98-9
Chemical Structure
Embricitinib
Synonym(s): JAK1-IN-18
- CAS No.: 2459377-98-9
- Formula:C16H20F2N6O2
- Molecular Weight:366.37
IUPAC Name: (S)-4-((3-((2,2-difluoroethyl)carbamoyl)piperidin-1-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
InChIKey: WOWPHKPPVWFLPO-VIFPVBQESA-N
SMILES: O=C(NCC(F)F)[C@@H]1CN(CCC1)NC2=C3C(NC=C3)=NC=C2C(N)=O
Biological Activity: Embricitinib (JAK1-IN-18) (Example 2) is a selective JAK1 inhibitor with an IC50 of 0.15 nM for JAK1 over JAK2 and JAK3. Embricitinib significantly reduces inflammation in DSS (HY-116282C)-induced ulcerative colitis (UC) mouse models and DNBS(HY-W324435)-induced Crohn's disease (CD) rat models. Embricitinib can be used for autoimmune diseases (such as inflammatory bowel disease), viral infections (such as HBV infection) and cancers (such as blood cancer) research[1].
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Embricitinib | Embricitinib (JAK1-IN-18) (Example 2) is a selective JAK1 inhibitor with an IC50 of 0.15 nM for JAK1 over JAK2 and JAK3. Embricitinib significantly reduces inflammation in DSS (HY-116282C)-induced ulcerative colitis (UC) mouse models and DNBS(HY-W324435)-induced Crohn's disease (CD) rat models. Embricitinib can be used for autoimmune diseases (such as inflammatory bowel disease), viral infections (such as HBV infection) and cancers (such as blood cancer) research. | |||||||||||||||||||||
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