2459377-98-9
Chemical Structure
JAK1-IN-18
- CAS No.: 2459377-98-9
- Formula:C16H20F2N6O2
- Molecular Weight:366.37
IUPAC Name: (S)-4-((3-((2,2-difluoroethyl)carbamoyl)piperidin-1-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
InChIKey: WOWPHKPPVWFLPO-VIFPVBQESA-N
SMILES: O=C(NCC(F)F)[C@@H]1CN(CCC1)NC2=C3C(NC=C3)=NC=C2C(N)=O
Biological Activity: JAK1-IN-18 (Example 2) is a selective JAK1 inhibitor with an IC50 of 0.15 nM for JAK1 over JAK2 and JAK3. JAK1-IN-18 significantly reduces inflammation in DSS (HY-116282C)-induced ulcerative colitis (UC) mouse models and DNBS(HY-W324435)-induced Crohn's disease (CD) rat models. JAK1-IN-18 can be used for autoimmune diseases (such as inflammatory bowel disease), viral infections (such as HBV infection) and cancers (such as blood cancer) research[1].
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JAK1-IN-18 | JAK1-IN-18 (Example 2) is a selective JAK1 inhibitor with an IC50 of 0.15 nM for JAK1 over JAK2 and JAK3. JAK1-IN-18 significantly reduces inflammation in DSS (HY-116282C)-induced ulcerative colitis (UC) mouse models and DNBS(HY-W324435)-induced Crohn's disease (CD) rat models. JAK1-IN-18 can be used for autoimmune diseases (such as inflammatory bowel disease), viral infections (such as HBV infection) and cancers (such as blood cancer) research. | |||||||||||||||||||||
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Keywords
