1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. Tyk2-IN-7

Tyk2-IN-7 

Cat. No.: HY-126242S
Handling Instructions

Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model.

For research use only. We do not sell to patients.

Tyk2-IN-7 Chemical Structure

Tyk2-IN-7 Chemical Structure

CAS No. : 1609391-90-3

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Description

Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

IC50 & Target

Tyk2 JH2

0.00053 μM (IC50)

Tyk2 JH2

0.00007 μM (Ki app)

Molecular Weight

401.46

Formula

C₁₈H₁₅D₃N₆O₃S

CAS No.

1609391-90-3

SMILES

O=C(NC([2H])([2H])[2H])C1=NN=C(NC2=CC=CC=N2)C=C1NC3=CC=CC=C3S(=O)(C)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Tyk2-IN-7
Cat. No.:
HY-126242S
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