1609392-06-4
Chemical Structure
Tyk2-IN-14
- CAS No.: 1609392-06-4
- Formula:C18H18N6O3S
- Molecular Weight:398.44
IUPAC Name: N-methyl-4-((2-(methylsulfonyl)phenyl)amino)-6-(pyridin-2-ylamino)pyridazine-3-carboxamide
InChIKey: KUHISBZXQSKCLH-UHFFFAOYSA-N
SMILES: O=C(NC)C1=NN=C(C=C1NC=2C=CC=CC2S(=O)(=O)C)NC3=NC=CC=C3
Biological Activity: Tyk2-IN-14 is a Tyk2 inhibitor that regulates IFNα and IL-23 by inhibiting Tyk2-mediated signal transduction. Tyk2-IN-14 exhibits an IC50 of 0.08 μM against the IL-23 Kit225 reporter gene and an IC50 of 0.09 μM against the IFNα Kit225 reporter gene. IL-23 modulator-1 is applicable to the research of inflammatory diseases and autoimmune diseases[1].
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Tyk2-IN-14 | Tyk2-IN-14 is a Tyk2 inhibitor that regulates IFNα and IL-23 by inhibiting Tyk2-mediated signal transduction. Tyk2-IN-14 exhibits an IC50 of 0.08 μM against the IL-23 Kit225 reporter gene and an IC50 of 0.09 μM against the IFNα Kit225 reporter gene. IL-23 modulator-1 is applicable to the research of inflammatory diseases and autoimmune diseases. | |||||||||||||||||||||
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Tyk2-IN-7 | 99.58% | Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis. | ||||||||||||||||||||
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Keywords
