STAT2 - signal transducer and activator of transcription 2 Gene

Also Known as P113; IMD44; ISGF-3; PTORCH3; STAT113

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6773

About STAT2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,341,597-56,360,107 (from NCBI)

This gene has 42 transcripts (splice variants), 197 orthologues, 6 paralogues and is associated with 5 phenotypes. Ubiquitous expression in spleen (RPKM 31.9), appendix (RPKM 25.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the STAT protein family. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate Antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]

STAT2 Products (7)

mRNA	Protein	Name
NM_001385110.1	NP_001372039.1	signal transducer and activator of transcription 2 isoform 3
NM_001385111.1	NP_001372040.1	signal transducer and activator of transcription 2 isoform 4
NM_001385113.1	NP_001372042.1	signal transducer and activator of transcription 2 isoform 5
NM_001385114.1	NP_001372043.1	signal transducer and activator of transcription 2 isoform 6
NM_001385115.1	NP_001372044.1	signal transducer and activator of transcription 2 isoform 7
NM_005419.4	NP_005410.1	signal transducer and activator of transcription 2 isoform 1
NM_198332.2	NP_938146.1	signal transducer and activator of transcription 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9020188	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9020188	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	8605877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8605876	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	27782195	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	23139419	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	23391734	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28165510	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24065129	GOA
involved in regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	26122121	GOA
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	26122121	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9020188	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23391734	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ISGF3 complex	IPI IPI: Inferred from physical interaction	24065129	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	23139419	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAT2 Protein Structure

STAT_int

STAT_alpha

STAT_bind

SH2

STAT2_C

0
200
400
600
800
851 a.a.

Protein Preferred Names	Protein Names
signal transducer and activator of transcription 2	interferon alpha induced transcriptional activator

STAT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STAT2	P52630	STAT1	Homo sapiens	P42224	CoIP	8605877
Intra	STAT2	P52630	STAT1	Homo sapiens	P42224	Crosslink	24065129
Intra	STAT2	P52630	STAT1	Homo sapiens	P42224	Competition Binding	8605877
Intra	STAT2	P52630	STAT1	Homo sapiens	P42224	Anti Tag CoIP	33961781
Intra	STAT2	P52630	STAT1	Homo sapiens	P42224	Anti Bait CoIP	17923090
Intra	STAT2	P52630	TYK2	Homo sapiens	P29597	Anti Tag CoIP	34521819
Intra	STAT2	P52630	TYK2	Homo sapiens	P29597	Anti Tag CoIP	32953130
Intra	STAT2	P52630	IFNAR1	Homo sapiens	P17181	Pull Down	8605876
Intra	STAT2	P52630	IFNAR1	Homo sapiens	P17181	SPR	12220192
Intra	STAT2	P52630	IFNAR1	Homo sapiens	P17181	Anti Bait CoIP	9677371
Cross	STAT2	P52630	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	32953130
Cross	STAT2	P52630	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34521819
Cross	STAT2	P52630	P/V	measles virus	P0C774	Pull Down	18579593
Intra	STAT2	P52630	IRF9	Homo sapiens	Q00978	Anti Tag CoIP	17923090
Intra	STAT2	P52630	IRF9	Homo sapiens	Q00978	Crosslink	24065129
Intra	STAT2	P52630	IRF9	Homo sapiens	Q00978	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

STAT2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80343	STAT2 Antibody (YA057)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P86182	STAT2 Antibody (YA5874)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pseudo-Torch Syndrome 3	PTORCH3
Immunodeficiency 44	IMD44
Primary Immunodeficiency With Post-Measles-Mumps-Rubella Vaccine Viral Infection	Primary Immunodeficiency With Post-Mmr Vaccine Viral Infection
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Rabies	Lyssa Hydrophobia St Hubert Disease
Torch Syndrome
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Thrombotic Microangiopathy	Tma
Vaccinia
Kunjin Encephalitis
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Immunodeficiency 28	IMD28 Ifngr2 Deficiency Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive Immunodeficiency 28, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency Msmd Due To Complete Ifngammar2 Deficiency Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency Immunodeficiency, Type 28, Mycobacteriosis
Immunodeficiency 35	Tyrosine Kinase 2 Deficiency IMD35 Tyk2 Deficiency Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis Susceptibility To Infection Due To Tyk2 Deficiency Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive Hies With Atypical Mycobacteriosis, Autosomal Recessive Autosomal Recessiv Hies With Atypical Mycobacteriosis Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency Autosomal Recessive Hies With Atypical Mycobacteriosis
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Dengue Shock Syndrome	Dss
Herpangina	Vesicular Pharyngitis
Dengue Hemorrhagic Fever	Severe Dengue Dengue Haemorrhagic Fever Dhf Severe Dengue Haemorrhagic Fever Severe Dengue Fever Dengue Shock Syndrome
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Zika Fever	Zika Virus Infection Zika Virus Disease Zika Virus Zika Virus Fever Mosquito-Borne Viral Fever, Zika
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W722277A	LCC-12 formate	Inhibitor	99.90%	Unkown
HY-169853	M351-0056		99.48%	Unkown
HY-172946	SD-2301	Degrader	/	Unkown
HY-RS13887	STAT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17307	Stat2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23762	Stat2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-150895	SI-191	Ligand	/	Unkown
HY-172907	SMU-1k	Inhibitor	/	Unkown
HY-174428	PROTAC JAK2 degrader-1		/	Unkown
HY-178936	JAK2-IN-15	Inhibitor	/	Unkown
HY-184119	Pabgraminone C		/	Unkown
HY-174665	Human IFNAR2 mRNA		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99666	Interferon alfa-2b	Agonist	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STAT2	VGNC	VGNC:77905
Felis catus	STAT2	VGNC	VGNC:65760
Rattus norvegicus	STAT2	RGD	RGD:1311649
Bos taurus	STAT2	VGNC	VGNC:35370
Mus musculus	STAT2	MGD	MGI:103039
Canis familiaris	STAT2	VGNC	VGNC:108218
Others	STAT2	NCBI