IRF9 - interferon regulatory factor 9 Gene

Also Known as p48; IRF-9; ISGF3; ISGF3G

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10379

About IRF9

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,161,265-24,166,565 (from NCBI)

This gene has 70 transcripts (splice variants), 1 gene allele, 277 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 55.3), appendix (RPKM 34.4) and 25 other tissues.

Summary

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, Apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]

IRF9 Products (4)

mRNA	Protein	Name
NM_001385400.1	NP_001372329.1	interferon regulatory factor 9 isoform 1
NM_001385401.1	NP_001372330.1	interferon regulatory factor 9 isoform 3
NM_001385402.1	NP_001372331.1	interferon regulatory factor 9 isoform 4
NM_006084.5	NP_006075.3	interferon regulatory factor 9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	24882218	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17923090	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24065129	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ISGF3 complex	IPI IPI: Inferred from physical interaction	24065129	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF9 Protein Structure

IRF

IRF-3

0
100
200
300
393 a.a.

Protein Preferred Names	Protein Names
interferon regulatory factor 9	IFN-alpha-responsive transcription factor subunit

IRF9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Tag CoIP	21903422
Intra	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Bait CoIP	17923090
Intra	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Tag CoIP	33961781
Intra	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Tag CoIP	28514442
Intra	IRF9	Q00978	STAT2	Homo sapiens	P52630	Crosslink	24065129
Intra	IRF9	Q00978	IFNAR2	Homo sapiens	P48551	Anti Tag CoIP	17923090
Intra	IRF9	Q00978	IFNAR2	Homo sapiens	P48551	Anti Bait CoIP	17923090

Cross: Cross-species interaction Intra: Intraspecies interaction

IRF9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82178	IRF9 Antibody (YA1923)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Immunodeficiency 65 Viral Infections	Immunodeficiency 65, Susceptibility To Viral Infections IMD65 Immunodeficiency 65
Immunodeficiency 65	Imd65 Immunodeficiency 65, Susceptibility To Viral Infections
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Immunodeficiency 44	IMD44
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Immunodeficiency 39	IMD39 Immunodeficiency, Type 39
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Lymphopenia	Lymphocytopenia
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Phlebotomus Fever	Pappataci Fever Sandfly Fever Sandfly-Borne Phleboviral Disease Sandfly-Borne Arboviral Fever Sandfly-Borne Bunyavirus Fever Three Day Fever Chitral Fever Italy Summer Grippe Italy Summer Grippe Influenza
Torch Syndrome
Herpangina	Vesicular Pharyngitis
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06913	IRF9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17690	Irf9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24152	Irf9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99666	Interferon alfa-2b	Agonist	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRF9	MGD	MGI:107587
Rattus norvegicus	IRF9	RGD	RGD:1308766
Felis catus	IRF9	VGNC	VGNC:80948
Canis familiaris	IRF9	VGNC	VGNC:42097
Macaca mulatta	IRF9	VGNC	VGNC:84361
Bos taurus	IRF9	VGNC	VGNC:30280
Others	IRF9	NCBI