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KHDRBS2 - KH RNA binding domain containing, signal transduction associated 2 Gene

Also Known as SLM1; SLM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 202559

About KHDRBS2

Cytogenetic location: 6q11.1 Genomic coordinates (GRCh38): 6:61,542,670-62,286,225 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable mRNA binding activity and poly(A) binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

KHDRBS2 Products (2)

mRNA	Protein	Name
NM_001350622.2	NP_001337551.1	KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform 1
NM_152688.4	NP_689901.2	KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KHDRBS2 Protein Structure

KH_1

0
100
200
300
349 a.a.

Protein Preferred Names	Protein Names
KH domain-containing, RNA-binding, signal transduction-associated protein 2	KH domain containing, RNA binding, signal transduction associated 2

KHDRBS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KHDRBS2	Q5VWX1	SULT1A3	Homo sapiens	P0DMM9	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	SULT1A3	Homo sapiens	P0DMM9	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	ZNF497	Homo sapiens	Q6ZNH5	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	FOXD4L3	Homo sapiens	Q6VB84	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	LMNTD2	Homo sapiens	Q8IXW0	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	KHDRBS1	Homo sapiens	Q07666	Anti Tag CoIP	33961781
Intra	KHDRBS2	Q5VWX1	TYK2	Homo sapiens	P29597	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	TYK2	Homo sapiens	P29597	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	PTK6	Homo sapiens	Q13882	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	27107012
Intra	KHDRBS2	Q5VWX1	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	PRR3	Homo sapiens	P79522	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	PRR3	Homo sapiens	P79522	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	YTHDC1	Homo sapiens	Q96MU7	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	YTHDC1	Homo sapiens	Q96MU7	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	NABP1	Homo sapiens	Q96AH0	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	NABP1	Homo sapiens	Q96AH0	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	RBM3	Homo sapiens	P98179	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	RBM3	Homo sapiens	P98179	Y2H Array	29892012
Intra	KHDRBS2	Q5VWX1	CHTOP	Homo sapiens	Q9Y3Y2	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	DOCK2	Homo sapiens	Q92608	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	CIRBP	Homo sapiens	Q14011	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	CIRBP	Homo sapiens	Q14011	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	ZFC3H1	Homo sapiens	G3V1X1	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	ZFC3H1	Homo sapiens	G3V1X1	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	HNRNPR	Homo sapiens	O43390	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	MTA1	Homo sapiens	Q13330	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	MTA1	Homo sapiens	Q13330	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	SPG7	Homo sapiens	Q9UQ90	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	HBZ	Homo sapiens	P02008	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	KHDRBS2	Q5VWX1	KHDRBS3	Homo sapiens	O75525	Anti Tag CoIP	33961781
Intra	KHDRBS2	Q5VWX1	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	KHDRBS2	Q5VWX1	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	TYMSOS	Homo sapiens	Q8TAI1	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	BAHD1	Homo sapiens	Q8TBE0	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	RBMX	Homo sapiens	P38159	Pull Down	16189514
Intra	KHDRBS2	Q5VWX1	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	32296183
Intra	KHDRBS2	Q5VWX1	RBMX	Homo sapiens	P38159	Y2H Array	32296183
Intra	KHDRBS2	Q5VWX1	RBMX	Homo sapiens	P38159	Validated Y2H	27107012
Intra	KHDRBS2	Q5VWX1	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	CATSPER1	Homo sapiens	Q8NEC5	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	CATSPER1	Homo sapiens	Q8NEC5	Y2H Prey Pooling	25416956
Intra	KHDRBS2	Q5VWX1	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	NPDC1	Homo sapiens	Q9NQX5	Validated Y2H	32296183
Intra	KHDRBS2	Q5VWX1	NPDC1	Homo sapiens	Q9NQX5	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	AEN	Homo sapiens	Q8WTP8	Validated Y2H	25416956
Intra	KHDRBS2	Q5VWX1	AEN	Homo sapiens	Q8WTP8	Y2H Array	25416956
Intra	KHDRBS2	Q5VWX1	RBM14	Homo sapiens	Q96PK6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KHDRBS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84636	KHDRBS2 Antibody (YA4333)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84636A	KHDRBS2 Antibody (YA4333)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07238	KHDRBS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KHDRBS2	VGNC	VGNC:42336
Bos taurus	KHDRBS2	VGNC	VGNC:30541
Macaca mulatta	KHDRBS2	VGNC	VGNC:104409
Mus musculus	KHDRBS2	MGD	MGI:2159649
Rattus norvegicus	KHDRBS2	RGD	RGD:621738
Felis catus	KHDRBS2	VGNC	VGNC:102445
Others	KHDRBS2	NCBI