HNRNPR - heterogeneous nuclear ribonucleoprotein R Gene

Homo sapiens

Also known as HNRPR; NEDDFSB; hnRNP-R

Gene ID: 10236 | Gene type: protein coding

About HNRNPR

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,304,688-23,344,284 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 236 orthologues, 24 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 17.7), appendix (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

HNRNPR Products(7)

mRNA	Protein	Name
NM_001102397.3	NP_001095867.1	heterogeneous nuclear ribonucleoprotein R isoform 4
NM_001102398.3	NP_001095868.1	heterogeneous nuclear ribonucleoprotein R isoform 1
NM_001102399.3	NP_001095869.1	heterogeneous nuclear ribonucleoprotein R isoform 3
NM_001297620.2	NP_001284549.1	heterogeneous nuclear ribonucleoprotein R isoform 5
NM_001297621.2	NP_001284550.1	heterogeneous nuclear ribonucleoprotein R isoform 7
NM_001297622.2	NP_001284551.1	heterogeneous nuclear ribonucleoprotein R isoform 6
NM_005826.5	NP_005817.1	heterogeneous nuclear ribonucleoprotein R isoform 2

HNRNPR Protein Structure

RRM_1

0
100
200
300
400
500
633 a.a.

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein R

Recombinant HNRNPR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73920	hnRNP-R Protein, Human (sf9, His-GST)	O43390-2 (A2-K636)	≥95%

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Dysmorphic Facies And Skeletal And Brain Abnormalities

NEDDFSB

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Spinal Muscular Atrophy, Type Iii

SMA3	Juvenile Spinal Muscular Atrophy
Kugelberg-Welander Disease	Sma Iii
Kugelberg-Welander Syndrome	Kws
Muscular Atrophy, Juvenile	Spinal Muscular Atrophy, Mild Childhood And Adolescent Form
Spinal Muscular Atrophy-3	Spinal Muscular Atrophy Type 3
Spinal Muscular Atrophy, Type Iii, Modifier Of	Type Iii Spinal Muscular Atrophy
Sma 3	Proximal Spinal Muscular Atrophy Type 3
Sma Type 3	Sma Type Iii
Sma-Iii	Spinal Muscular Atrophy 3
Spinal Muscular Atrophy Mild Childhood And Adolescent Form	Spinal Muscular Atrophy Type Iii
Wohlfart-Kugelberg-Welander Disease	Atrophy, Muscular, Spinal, Type Iii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06277	HNRNPR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HNRNPR	RGD	RGD:631348
Felis catus	HNRNPR	VGNC	VGNC:67612
Mus musculus	HNRNPR	MGD	MGI:1891692
Canis familiaris	HNRNPR	VGNC	VGNC:41735
Bos taurus	HNRNPR	VGNC	VGNC:29899
Macaca mulatta	HNRNPR	VGNC	VGNC:73499
Others	HNRNPR	NCBI

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