PRMT1 - protein arginine methyltransferase 1 Gene

Homo sapiens

Also known as ANM1; HCP1; IR1B4; HRMT1L2

Gene ID: 3276 | Gene type: protein coding

About PRMT1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,676,153-49,688,447 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 42.8), heart (RPKM 38.0) and 25 other tissues.

Summary

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

PRMT1 Products(9)

mRNA	Protein	Name
XM_047438742.1	XP_047294698.1	protein arginine N-methyltransferase 1 isoform X1
NR_033397.5
NM_198319.2
XM_017026735.2	XP_016882224.1	protein arginine N-methyltransferase 1 isoform X2
XM_017026736.2	XP_016882225.1	protein arginine N-methyltransferase 1 isoform X3
NM_001207042.3	NP_001193971.1	protein arginine N-methyltransferase 1 isoform 4
NM_001536.6	NP_001527.3	protein arginine N-methyltransferase 1 isoform 1
XM_047438743.1	XP_047294699.1	protein arginine N-methyltransferase 1 isoform X1
NM_198318.5	NP_938074.2	protein arginine N-methyltransferase 1 isoform 3

PRMT1 Protein Structure

Methyltransf_31

0
100
200
300
371 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 1

HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2	heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
highly conserved protein 1	histone-arginine N-methyltransferase PRMT1
interferon receptor 1-bound protein 4

Related Diseases

Diseases

Alias

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Ewings Sarcoma	Ewing'S Sarcoma
Peripheral Neuroepithelioma	Primitive Neuroectodermal Tumor
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Extraosseous Ewing Tumor	Askin Tumor
Ewing'S Family Localized Tumor	Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing Sarcoma	Localized Ewing'S Sarcoma
Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing'S Tumor
Pnet Of Thoracopulmonary Region	Ewing Family Of Tumors
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Spinal Cord Primitive Neuroectodermal Neoplasm

Spinal Cord Pnet

Spinal Cord Primitive Neuroectodermal Tumor

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Spinal Cord Neuroblastoma

Neuroblastoma Of The Spinal Cord

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.73%	Unkown
HY-18962	AMI-1	Inhibitor	≥98.0%	Unkown
HY-12970A	EPZ020411 hydrochloride	Inhibitor	98.15%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.78%	Unkown
HY-12970	EPZ020411	Inhibitor	98.06%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-122096	DCLX069	Inhibitor	98.38%	Unkown
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRMT1	VGNC	VGNC:103742
Macaca mulatta	PRMT1	VGNC	VGNC:97809
Canis familiaris	PRMT1	VGNC	VGNC:44995
Mus musculus	PRMT1	MGD	MGI:107846
Bos taurus	PRMT1	VGNC	VGNC:52239
Rattus norvegicus	PRMT1	RGD	RGD:62020

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