SPSB1 - splA/ryanodine receptor domain and SOCS box containing 1 Gene

Homo sapiens

Also known as SSB1; SSB-1

Gene ID: 80176 | Gene type: protein coding

About SPSB1

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,292,894-9,369,532 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 16.9), gall bladder (RPKM 15.1) and 24 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SPSB1 Products(1)

mRNA	Protein	Name
NM_025106.4	NP_079382.2	SPRY domain-containing SOCS box protein 1

SPSB1 Protein Structure

SPRY

SOCS_box

0
100
200
273 a.a.

Protein Preferred Names

Protein Names

SPRY domain-containing SOCS box protein 1

SPRY domain-containing SOCS box protein SSB-1

Related Diseases

Diseases

Alias

Congenital Muscular Dystrophy-Dystroglycanopathy A7

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A7	Mddga7
Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease Ispd-Related	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13726	SPSB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPSB1	MGD	MGI:1921896
Canis familiaris	SPSB1	VGNC	VGNC:46770
Felis catus	SPSB1	VGNC	VGNC:65654
Macaca mulatta	SPSB1	VGNC	VGNC:78024
Rattus norvegicus	SPSB1	RGD	RGD:1309319

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