CCK - cholecystokinin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 885

About CCK

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,257,826-42,266,185 (from NCBI)

This gene has 4 transcripts (splice variants) and 259 orthologues. Biased expression in duodenum (RPKM 21.7), brain (RPKM 20.3) and 2 other tissues.

Summary

This gene encodes a member of the Gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide Hormones cholecystokinin-8, -12, -33, and Others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

CCK Products (2)

mRNA	Protein	Name
NM_000729.6	NP_000720.1	cholecystokinin preproprotein
NM_001174138.3	NP_001167609.1	cholecystokinin preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables peptide hormone receptor binding	IPI IPI: Inferred from physical interaction	7681836	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCK Protein Structure

Gastrin

0
100
115 a.a.

Protein Preferred Names	Protein Names
cholecystokinin	cholecystokinin triacontatriapeptide

CCK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCK	P06307	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32814053
Intra	CCK	P06307	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Pooling	32814053
Intra	CCK	P06307	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32814053
Intra	CCK	P06307	LPAL2	Homo sapiens	Q16609	Validated Y2H	32814053
Intra	CCK	P06307	LPAL2	Homo sapiens	Q16609	Y2H Pooling	32814053
Intra	CCK	P06307	LPAL2	Homo sapiens	Q16609	Y2H Array	32814053
Intra	CCK	P06307	RUSC1-AS1	Homo sapiens	Q66K80	Y2H Array	32814053
Intra	CCK	P06307	RUSC1-AS1	Homo sapiens	Q66K80	Validated Y2H	32814053
Intra	CCK	P06307	RUSC1-AS1	Homo sapiens	Q66K80	Y2H Pooling	32814053
Intra	CCK	P06307	ASCL4	Homo sapiens	Q6XD76	Y2H Array	32814053
Intra	CCK	P06307	ASCL4	Homo sapiens	Q6XD76	Y2H Pooling	32814053
Intra	CCK	P06307	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32814053
Intra	CCK	P06307	WBP1L	Homo sapiens	Q9NX94	Validated Y2H	32814053
Intra	CCK	P06307	WBP1L	Homo sapiens	Q9NX94	Y2H Pooling	32814053
Intra	CCK	P06307	WBP1L	Homo sapiens	Q9NX94	Y2H Array	32814053
Intra	CCK	P06307	RHEB	Homo sapiens	Q15382	Validated Y2H	32814053
Intra	CCK	P06307	RHEB	Homo sapiens	Q15382	Y2H Pooling	32814053
Intra	CCK	P06307	HCCS	Homo sapiens	P53701	Y2H Pooling	32814053
Intra	CCK	P06307	HCCS	Homo sapiens	P53701	Validated Y2H	32814053
Intra	CCK	P06307	HCCS	Homo sapiens	P53701	Y2H Array	32814053
Intra	CCK	P06307	NAGK	Homo sapiens	Q9UJ70-2	Y2H Array	32814053
Intra	CCK	P06307	NAGK	Homo sapiens	Q9UJ70-2	Y2H Pooling	32814053
Intra	CCK	P06307	NAGK	Homo sapiens	Q9UJ70-2	Validated Y2H	32814053
Intra	CCK	P06307	CFAP100	Homo sapiens	Q494V2-2	Validated Y2H	32814053
Intra	CCK	P06307	CFAP100	Homo sapiens	Q494V2-2	Y2H Array	32814053
Intra	CCK	P06307	CFAP100	Homo sapiens	Q494V2-2	Y2H Pooling	32814053
Intra	CCK	P06307	SYMPK	Homo sapiens	Q92797-2	Y2H Array	32814053
Intra	CCK	P06307	SYMPK	Homo sapiens	Q92797-2	Y2H Pooling	32814053
Intra	CCK	P06307	SYMPK	Homo sapiens	Q92797-2	Validated Y2H	32814053
Intra	CCK	P06307	ESRP1	Homo sapiens	Q6NXG1-3	Y2H Pooling	32814053
Intra	CCK	P06307	ESRP1	Homo sapiens	Q6NXG1-3	Validated Y2H	32814053
Intra	CCK	P06307	ESRP1	Homo sapiens	Q6NXG1-3	Y2H Array	32814053
Intra	CCK	P06307	RGR	Homo sapiens	P47804-3	Y2H Array	32814053
Intra	CCK	P06307	RGR	Homo sapiens	P47804-3	Validated Y2H	32814053
Intra	CCK	P06307	RGR	Homo sapiens	P47804-3	Y2H Pooling	32814053
Intra	CCK	P06307	VPS54	Homo sapiens	Q9P1Q0-4	Y2H Array	32814053
Intra	CCK	P06307	VPS54	Homo sapiens	Q9P1Q0-4	Y2H Pooling	32814053
Intra	CCK	P06307	VPS54	Homo sapiens	Q9P1Q0-4	Validated Y2H	32814053
Intra	CCK	P06307	LHX5	Homo sapiens	Q9H2C1	Validated Y2H	32814053
Intra	CCK	P06307	LHX5	Homo sapiens	Q9H2C1	Y2H Array	32814053
Intra	CCK	P06307	LHX5	Homo sapiens	Q9H2C1	Y2H Pooling	32814053
Intra	CCK	P06307	PRPH2	Homo sapiens	P23942	Y2H Array	32814053
Intra	CCK	P06307	PRPH2	Homo sapiens	P23942	Validated Y2H	32814053
Intra	CCK	P06307	PRPH2	Homo sapiens	P23942	Y2H Pooling	32814053
Intra	CCK	P06307	EPM2A	Homo sapiens	O95278-6	Y2H Array	32814053
Intra	CCK	P06307	EPM2A	Homo sapiens	O95278-6	Validated Y2H	32814053
Intra	CCK	P06307	EPM2A	Homo sapiens	O95278-6	Y2H Pooling	32814053
Intra	CCK	P06307	ATG12	Homo sapiens	C1IDX9	Y2H Pooling	32814053
Intra	CCK	P06307	ATG12	Homo sapiens	C1IDX9	Validated Y2H	32814053
Intra	CCK	P06307	ATG12	Homo sapiens	C1IDX9	Y2H Array	32814053
Intra	CCK	P06307	CITED1	Homo sapiens	Q99966	Y2H Array	32814053
Intra	CCK	P06307	CITED1	Homo sapiens	Q99966	Y2H Pooling	32814053
Intra	CCK	P06307	CITED1	Homo sapiens	Q99966	Validated Y2H	32814053
Intra	CCK	P06307	SLFN12	Homo sapiens	Q8IYM2	Y2H Array	32814053
Intra	CCK	P06307	SLFN12	Homo sapiens	Q8IYM2	Y2H Pooling	32814053
Intra	CCK	P06307	SLFN12	Homo sapiens	Q8IYM2	Validated Y2H	32814053
Intra	CCK	P06307	SPRY4	Homo sapiens	Q9C004	Y2H Array	32814053
Intra	CCK	P06307	SPRY4	Homo sapiens	Q9C004	Validated Y2H	32814053
Intra	CCK	P06307	SPRY4	Homo sapiens	Q9C004	Y2H Pooling	32814053
Intra	CCK	P06307	NFYB	Homo sapiens	P25208	Y2H Array	32814053
Intra	CCK	P06307	NFYB	Homo sapiens	P25208	Y2H Pooling	32814053
Intra	CCK	P06307	NFYB	Homo sapiens	P25208	Validated Y2H	32814053
Intra	CCK	P06307	CBX4	Homo sapiens	O00257-3	Validated Y2H	32814053
Intra	CCK	P06307	CBX4	Homo sapiens	O00257-3	Y2H Array	32814053
Intra	CCK	P06307	CBX4	Homo sapiens	O00257-3	Y2H Pooling	32814053
Intra	CCK	P06307	MYC	Homo sapiens	P01106	Y2H Array	32814053
Intra	CCK	P06307	MYC	Homo sapiens	P01106	Validated Y2H	32814053
Intra	CCK	P06307	MYC	Homo sapiens	P01106	Y2H Pooling	32814053
Intra	CCK	P06307	FYN	Homo sapiens	P06241	Y2H Array	32814053
Intra	CCK	P06307	FYN	Homo sapiens	P06241	Y2H Pooling	32814053
Intra	CCK	P06307	FYN	Homo sapiens	P06241	Validated Y2H	32814053
Intra	CCK	P06307	ARL6IP4	Homo sapiens	Q66PJ3-4	Validated Y2H	32814053
Intra	CCK	P06307	ARL6IP4	Homo sapiens	Q66PJ3-4	Y2H Array	32814053
Intra	CCK	P06307	ARL6IP4	Homo sapiens	Q66PJ3-4	Y2H Pooling	32814053
Intra	CCK	P06307	H2AP	Homo sapiens	O75409	Y2H Pooling	32814053
Intra	CCK	P06307	H2AP	Homo sapiens	O75409	Validated Y2H	32814053
Intra	CCK	P06307	H2AP	Homo sapiens	O75409	Y2H Array	32814053
Intra	CCK	P06307	PPBP	Homo sapiens	P02775	Y2H Pooling	32814053
Intra	CCK	P06307	PPBP	Homo sapiens	P02775	Validated Y2H	32814053
Intra	CCK	P06307	PPBP	Homo sapiens	P02775	Y2H Array	32814053
Intra	CCK	P06307	JPT1	Homo sapiens	Q9UK76	Y2H Pooling	32814053
Intra	CCK	P06307	JPT1	Homo sapiens	Q9UK76	Validated Y2H	32814053
Intra	CCK	P06307	JPT1	Homo sapiens	Q9UK76	Y2H Array	32814053
Intra	CCK	P06307	RELA	Homo sapiens	Q04206	Y2H Array	32814053
Intra	CCK	P06307	RELA	Homo sapiens	Q04206	Validated Y2H	32814053
Intra	CCK	P06307	RELA	Homo sapiens	Q04206	Y2H Pooling	32814053
Intra	CCK	P06307	NUP54	Homo sapiens	Q7Z3B4	Y2H Pooling	32814053
Intra	CCK	P06307	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32814053
Intra	CCK	P06307	NUP54	Homo sapiens	Q7Z3B4	Y2H Array	32814053
Intra	CCK	P06307	SH3BP5L	Homo sapiens	Q7L8J4	Validated Y2H	32814053
Intra	CCK	P06307	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Pooling	32814053
Intra	CCK	P06307	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Array	32814053
Intra	CCK	P06307	CHMP7	Homo sapiens	Q8WUX9	Y2H Array	32814053
Intra	CCK	P06307	CHMP7	Homo sapiens	Q8WUX9	Validated Y2H	32814053
Intra	CCK	P06307	CHMP7	Homo sapiens	Q8WUX9	Y2H Pooling	32814053
Intra	CCK	P06307	KRT222	Homo sapiens	Q8N1A0	Y2H Array	32814053
Intra	CCK	P06307	KRT222	Homo sapiens	Q8N1A0	Validated Y2H	32814053
Intra	CCK	P06307	KRT222	Homo sapiens	Q8N1A0	Y2H Pooling	32814053
Intra	CCK	P06307	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CCK	P06307	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CCK	P06307	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cholecystitis	Acute Cholecystitis Chronic Cholecystitis Acalculous Cholecystitis Acute And Chronic Cholecystitis Acute On Chronic Cholecystitis Gallstone Cholecystitis Cholecystitis, Acute Calculus Of Gallbladder With Cholecystitis Gallbladder Inflammation Acute Cholecystitis Infection Acute Acalculous Cholecystitis Chronic Acalculous Cholecystitis Nonfunctioning Gallbladder
Biliary Dyskinesia	Sphincter Of Oddi Dysfunction
Bulimia Nervosa	Bulimia Bulimia Nervosa, Susceptibility To Binge Eating Disorder BULN Bn Hyperorexia Nervosa Bulimia Nervosa 2 BULN2 Susceptibility To Bulimia Nervosa Bulimia Nervosa, Susceptibility To, Type 2 Bn - [Bulimia Nervosa] Bulimia Nos Bulimic Bingeing Binge Overeating Bouts Of Overeating Episodes Of Overeating
Cholelithiasis
Acalculous Cholecystitis	Acute Cholecystitis Without Calculus Acute Acalculous Cholecystitis Cholecystitis Without Calculus
Gallbladder Disease	Gallbladder Diseases Gall Bladder Gall Bladder Diseases Abnormal Gallbladder Function
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Exocrine Pancreatic Insufficiency
Acute Pancreatitis	Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Nos Acute Pancreas Inflammation
Opioid Abuse	Opioid-Related Disorders
Bile Reflux
Pancreas Disease	Abnormality Of The Pancreas Pancreatic Diseases
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Duodenogastric Reflux
Pancreatitis	Mumps Pancreatitis
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Morphine Dependence
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Duodenal Ulcer	Stress Ulcer Curling Ulcer Stress Ulcer Of Stomach Curling'S Ulcers Duodenal Ulcer Disease Duodenal Ulcers Duodenal Peptic Ulcer
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Short Bowel Syndrome	Short Gut Syndrome Acquired Short Bowel Syndrome Secondary Short Bowel Syndrome Short Bowel Nos
Social Phobia	Phobia, Social Phobia Social Phobic Anxiety Disorder
Acute Hemorrhagic Pancreatitis	Pancreatitis, Acute Hemorrhagic
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Headache	Headache Disorder
Alcoholic Pancreatitis	Pancreatitis, Alcoholic Pancreatitis Alcoholic
Dumping Syndrome	Jejunal Syndrome Dumping Dumping Syndrome Postgastrectomy Syndromes Postgastric Surgery Syndrome Postgastrectomy Syndrome Post Cibal Syndrome Postgastrectomy Dumping Syndrome
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Postcholecystectomy Syndrome	Post Cholecystectomy Syndrome
Constipation
Cholestasis	Obstruction Of Bile Duct Bile Duct Obstruction Bile Occlusion Extrahepatic Biliary Obstruction Extrahepatic Bile Duct Obstruction Bile Stasis Biliary Stasis Obstructive Hyperbilirubinemia Obstructed Jaundice Bile Duct Obstructed Bile Ductal Obstruction Biliary Duct Obstruction Obstructed Bile Ductal Obstructed Biliary Duct Obstructed Biliary Ductal Jaundice Regurgitation Obstructive Jaundice Cholestatic Jaundice Cholestatic Jaundice Syndrome
Menkes Disease	Copper Transport Disease Menkes Syndrome MNK Kinky Hair Disease Steely Hair Disease Menkes Kinky-Hair Syndrome Mk Steely Hair Syndrome Menkea Syndrome Md Menkes Kinky Hair Syndrome Hypocupremia, Congenital Kinky Hair Syndrome X-Linked Copper Deficiency Menkes Kinky Hair Disease
Gastrointestinal System Disease	Gastrointestinal Disease Gastrointestinal Diseases Alimentary System Disease Digestive System Disorder Gastroenteropathy Gastrointestinal Disorder Git Disease Digestive System Diseases Gastrointestinal Disorders Digestive System Disease Digestive System Disorders
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Obstructive Jaundice	Jaundice, Obstructive Cholestatic Jaundice Cholestatic Jaundice Syndrome Obstructive Hyperbilirubinemia Jaundice Obstructive Jaundice Cholestatic
Hyperglycemia
Nutritional Deficiency Disease	Malnutrition Nutritional Disorder Nutritional Deficiency Nutrition Deficiency Diseases Carbamoyl-Phosphate Synthase I Deficiency Disease Nutrition Disorders
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Functional Gastric Disease
Functionless Pituitary Adenoma	Non-Functioning Neoplasm Of The Pituitary Non-Secretory Adenoma Of The Pituitary Gland Non-Functioning Pituitary Gland Neoplasm
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Acute Necrotizing Pancreatitis	Pancreatitis, Acute Necrotizing
Protein-Energy Malnutrition	PEM Protein Energy Malnutrition
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Common Bile Duct Disease	Common Bile Duct Diseases
Cholecystolithiasis
Occlusion Of Gallbladder	Obstruction Of Gallbladder Gallbladder Obstruction
Pain Agnosia	Analgesia
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Kluver-Bucy Syndrome	Bilateral Temporal Lobe Disorder Klüver-Bucy Syndrome Klver-Bucy Syndrome Kluver Bucy Syndrome Memory Loss, Extreme Sexual Behavior, Placidity, And Visual Distractibility Post-Encephalitic Kluver Bucy Syndrome Post-Traumatic Kluver Bucy Syndrome
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Choledocholithiasis
Pancreatitis, Hereditary	Hereditary Pancreatitis Chronic Pancreatitis Hereditary Chronic Pancreatitis Hp Pancreatitis, Chronic, Susceptibility To PCTT Hpc Pancreatitis, Chronic Pancreatitis, Chronic, Protection Against Autosomal Dominant Hereditary Pancreatitis Familial Pancreatitis Cp Pancreatitis Hereditary
Peptic Ulcer Disease	Peptic Ulcer Acute Peptic Ulcer With Hemorrhage Acute Peptic Ulcer With Hemorrhage And Perforation Acute Peptic Ulcer Without Hemorrhage And Without Perforation
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Duodenitis	Hemorrhagic Duodenitis Acute Enteritis Of The Mouse Intestinal Tract Nonspecific Duodenitis Inflammation Of Duodenum Dodecadactylitis Duodenal Inflammation Peptic Duodenitis
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Diabetes Mellitus	Diabetes
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Volvulus Of Midgut	Volvulus Intestinal Volvulus Intestinal Malrotation, Familial Familial Intestinal Malrotation Twist Of Intestine, Bowel, Or Colon
Schizophrenia 14	Sczd14 Schizophrenia, Susceptibility To, 14 Schizophrenia Susceptibility Locus, Chromosome 2q32-Related
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Duodenal Obstruction
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia	APS1 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Apeced Pga I Hypoadrenocorticism With Hypoparathyroidism And Superficial Moniliasis Autoimmune Polyendocrinopathy Syndrome , Type I, With Or Without Reversible Metaphyseal Dysplasia Polyglandular Autoimmune Syndrome, Type 1 Autoimmune Polyglandular Syndrome Type 1 Autoimmune Polyendocrine Syndrome Type 1 Autoimmune Polyendocrinopathy Syndrome Type 1 Whitaker Syndrome Aps Type 1 Polyglandular Type I Autoimmune Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome Aps I Autoimmune Polyglandular Syndrome, Type I Polyglandular Autoimmune Syndrome, Type I Aps 1 Autoimmune Polyglandular Syndrome Type I Pga 1 Pga-I Polyglandular Autoimmune Syndrome Type 1 Type I Polyglandular Autoimmune Syndrome Aire Deficiency Autoimmune Polyendocrinopathy With Candidiasis And Ectodermal Dystrophy Autoimmune Polyglandular Syndrome, Type 1 Autoimmune Polyendocrinopathy Type 1 Apeced Syndrome Autoimmune Hypoparathyroidism-Chronic Candidiasis-Addison Disease Syndrome Ham Syndrome Hypoparathyroidism-Addison Disease-Mucocutaneous Candidiasis Syndrome Medac Syndrome Multiple Endocrine Deficiency-Addison Disease-Candidiasis Syndrome Autoimmune Polyendocrine Syndrome 1, With Or Without Reversible Metaphyseal Dysplasia Aps-1 Autoimmune Polyendocrine Syndrome Type I Autoimmune Polyendocrinopathy Syndrome Type I Autosomal Dominant Autoimmune Polyendocrinopathy Syndrome Type I Polyglandular Autoimmune Syndrome Type I Polyglandular Deficiency Syndrome Persian-Jewish Type Autoimmune Polyendocrinopathy Syndrome, Type I, Autosomal Dominant Polyendocrinopathy Autoimmune, Type 1, With/Without Reversible Metaphyseal Dysplasia
Anaerobic Meningitis
Gastroduodenal Crohn'S Disease	Upper Gi Crohn'S Disease
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Temporal Lobe Neoplasm	Neoplasm Of Temporal Lobe Malignant Neoplasm Of Temporal Lobe Tumor Of Temporal Lobe
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Specific Developmental Disorder
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Flying Phobia	Aerophobia
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0093	Sincalide		99.30%	Unkown
HY-B1330	Proglumide	Antagonist	99.84%	Yes
HY-P0093A	Sincalide ammonium		99.21%	Unkown
HY-103354	Proglumide sodium	Antagonist	99.58%	Yes
HY-103354A	Proglumide hemicalcium	Antagonist	/	Unkown

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128878	Dexloxiglumide	Antagonist	98.25%	Phase 3
HY-19445	Gastrazole	Antagonist	/	Phase 3
HY-106840	L-365260	Antagonist	99.85%	Phase 2
HY-14850	Sograzepide	Antagonist	98.04%	Phase 2
HY-101764	Lintitript	Antagonist	99.58%	Phase 2
HY-17617	Nastorazepide		99.95%	Phase 2
HY-105257	Pranazepide	Antagonist	99.81%	Phase 2
HY-106356	GV-150013	Antagonist	/	Phase 2
HY-11074	CE-326597	Agonist	/	Phase 2
HY-19261	T-0632	Antagonist	99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (96)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1097	Gastrin I, human		99.93%	Unkown
HY-P2671	[Leu15]-Gastrin I (human)		99.98%	Unkown
HY-106301	Devazepide	Antagonist	99.55%	Unkown
HY-103355	YM022	Antagonist	99.87%	Unkown
HY-P2932	Cholecystokinin		98.16%	Unkown
HY-125556	Tetragastrin	Agonist	99.89%	Unkown
HY-P0196	Cholecystokinin Octapeptide, desulfated		99.45%	Unkown
HY-B1439B	Lorglumide sodium	Antagonist	99.19%	Unkown
HY-P1096	A71623	Agonist	99.34%	Unkown
HY-107759	Butabindide oxalate	Inhibitor	98.98%	Unkown
HY-B2154	Loxiglumide	Antagonist	98.0%	Unkown
HY-111313	JNJ-26070109	Antagonist	99.25%	Unkown
HY-124187	Pinolenic acid ethyl ester		≥98.0%	Unkown
HY-101352	LY 225910	Antagonist	98.92%	Unkown
HY-106840A	L-365260 hemihydrate	Antagonist	99.75%	Unkown
HY-118194	A-65186	Antagonist	99.94%	Unkown
HY-148656	PNB-001	Antagonist	99.65%	Unkown
HY-U00360	(Rac)-Sograzepide	Antagonist	98.98%	Unkown
HY-105226B	CI-988 hemihydrate	Antagonist	≥99.0%	Unkown
HY-129357	CCK-B Receptor Antagonist 2	Inhibitor	98.84%	Unkown
HY-155205	GV150013X	Antagonist	99.75%	Unkown
HY-169914	Igmesine hydrochloride		/	Unkown
HY-P0196A	Cholecystokinin Octapeptide, desulfated TFA		97.17%	Unkown
HY-P2636	Cholecystokinin Precursor (24-32) (rat)		99.54%	Unkown
HY-P2677	CCK (26-31) sulfated		96.38%	Unkown
HY-P2932A	Cholecystokinin-33 free acid		95.77%	Unkown
HY-P3704	Enterostatin (rat)		98.16%	Unkown
HY-125314	AG-041R	Antagonist	99.9%	Unkown
HY-U00062	Tarazepide	Antagonist	/	Unkown
HY-100481	RP 72540	Antagonist	/	Unkown
HY-103279	BIM187	Agonist	/	Unkown
HY-103357	LY288513	Antagonist	/	Unkown
HY-103357A	LY262691	Antagonist	/	Unkown
HY-105226	CI-988	Antagonist	/	Unkown
HY-105226A	CI-988 meglumin	Antagonist	/	Unkown
HY-105955	FPL 14294		/	Unkown
HY-109028	Ceclazepide		/	Unkown
HY-111918	A71378	Agonist	/	Unkown
HY-113896	U-67827E	Agonist	/	Unkown
HY-116260	RP-69758	Antagonist	/	Unkown
HY-117781	GW-5823	Agonist	/	Unkown
HY-117828	PF-04756956	Inhibitor	/	Unkown
HY-117839	PD-135666	Inhibitor	/	Unkown
HY-118314	CI-1015		/	Unkown
HY-118546	JNJ-17156516	Antagonist	/	Unkown
HY-120381	PD 136450	Antagonist	/	Unkown
HY-121278	Benzotript	Antagonist	/	Unkown
HY-125431	LY 202769	Antagonist	/	Unkown
HY-128941	CCK2R Ligand-Linker Conjugates 1		/	Unkown
HY-14575	Nastorazepide hemicalcium		/	Unkown
HY-150070	Butabindide	Inhibitor	/	Unkown
HY-164634	CLIK-148	Inhibitor	/	Unkown
HY-172281	DSPE-PEG1000-CCK8		/	Unkown
HY-172281A	DSPE-PEG2000-CCK8		/	Unkown
HY-172281B	DSPE-PEG5000-CCK8		/	Unkown
HY-177506	FE100726	Agonist	/	Unkown
HY-177507	FE101120	Agonist	/	Unkown
HY-177508	BC264	Agonist	/	Unkown
HY-177509	BBL454	Agonist	/	Unkown
HY-186122	CCK2R agonist-1	Agonist	/	Unkown
HY-B1439	Lorglumide	Antagonist	/	Unkown
HY-P1133	Galanin (2-29) (rat)	Agonist	/	Unkown
HY-P1710	ARL 15849XX	Agonist	/	Unkown
HY-P1800	Caerulein, desulfated	Control	/	Unkown
HY-P1988	JMV 179	Antagonist	/	Unkown
HY-P1994A	JMV 170	Agonist	/	Unkown
HY-P2025	JMV 236		/	Unkown
HY-P2055	A-57696		/	Unkown
HY-P2121	JMV 176	Agonist	/	Unkown
HY-P2165	N-acetyl CCK-(26-30) amide	Antagonist	/	Unkown
HY-P2424	Cholecystokinin-J		/	Unkown
HY-P2592	Ro 23-7014		/	Unkown
HY-P2627	CCK (27-33)		/	Unkown
HY-P2638	Cholecystokinin (27-32)-amide	Antagonist	/	Unkown
HY-P2678	CCK (26-31) non-sulfated	Agonist	/	Unkown
HY-P3650	Cholecystokinin (1-21)		/	Unkown
HY-P3652	Cholecystokinin-33 (swine)	Agonist	/	Unkown
HY-P5526	CCK1-specific peptide substrate		/	Unkown
HY-RS02073	CCK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11995	RIPK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11996	Ripk2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-U00363	CHEMBL333994	Antagonist	/	Unkown
HY-U00363A	(rac)-CHEMBL333994	Control	/	Unkown
HY-116576	LY219057	Antagonist	/	Unkown
HY-118665	L-736380	Antagonist	/	Unkown
HY-118904	VL-0395	Antagonist	/	Unkown
HY-123434	PD-149164	Agonist	/	Unkown
HY-125610	DA-3934	Antagonist	/	Unkown
HY-129516	A-70874	Agonist	/	Unkown
HY-129759	KSG-504 anhydrous	Inhibitor	/	Unkown
HY-162070	CCK antagonist 1	Antagonist	99.96%	Unkown
HY-B1439BR	Lorglumide sodium (Standard)	Antagonist	/	Unkown
HY-RS16534	Cck Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22965	Cck Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-U00375	Gastrin/CCK antagonist 1	Antagonist	/	Unkown
HY-U00387	CCK-A receptor inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCK	VGNC	VGNC:26940
Mus musculus	CCK	MGD	MGI:88297
Rattus norvegicus	CCK	RGD	RGD:2288
Canis familiaris	CCK	VGNC	VGNC:52865
Felis catus	CCK	VGNC	VGNC:60535
Macaca mulatta	CCK	VGNC	VGNC:70716
Others	CCK	NCBI